Tracing the Origin of the Fungal α1 Domain Places Its Ancestor in the HMG-Box Superfamily: Implication for Fungal Mating-Type Evolution

Martin, Tom; Lu, Shun-Wen; van Tilbeurgh, Herman; Ripoll, Daniel R.; Dixelius, Christina; Turgeon, B. Gillian; Debuchy, Robert; Butler, Geraldine

doi:10.1371/journal.pone.0015199

Title: Tracing the Origin of the Fungal α1 Domain Places Its Ancestor in the HMG-Box Superfamily: Implication for Fungal Mating-Type Evolution

Journal Article · Wed Dec 08 00:00:00 EST 2010 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0015199· OSTI ID:1627438

Martin, Tom ^[1]; Lu, Shun-Wen ^[2]; van Tilbeurgh, Herman ^[3]; Ripoll, Daniel R. ^[2]; Dixelius, Christina ^[1]; Turgeon, B. Gillian ^[2]; Debuchy, Robert ^[2]; Butler, Geraldine ^[3]

Swedish University of Agricultural Sciences, Uppsala (Sweden)
Cornell University, Ithaca, NY (United States)
University Paris-Sud, Orsay (France)

Fungal mating types in self-incompatible Pezizomycotina are specified by one of two alternate sequences occupying the same locus on corresponding chromosomes. One sequence is characterized by a gene encoding an HMG protein, while the hallmark of the other is a gene encoding a protein with an α1 domain showing similarity to the Mata1p protein of Saccharomyces cerevisiae. DNA-binding HMG proteins are ubiquitous and well characterized. In contrast, α1 domain proteins have limited distribution and their evolutionary origin is obscure, precluding a complete understanding of mating-type evolution in Ascomycota. Although much work has focused on the role of the S. cerevisiae Matα1p protein as a transcription factor, it has not yet been placed in any of the large families of sequence-specific DNA-binding proteins. We present sequence comparisons, phylogenetic analyses, and in silico predictions of secondary and tertiary structures, which support our hypothesis that the α1 domain is related to the HMG domain. We have also characterized a new conserved motif in α1 proteins of Pezizomycotina. This motif is immediately adjacent to and downstream of the α1 domain and consists of a core sequence Y-[LMIF]-x(3)-G-[WL] embedded in a larger conserved motif. Our data suggest that extant α1-box genes originated from an ancestral HMG gene, which confirms the current model of mating-type evolution within the fungal kingdom. We propose to incorporate α1 proteins in a new subclass of HMG proteins termed MATα_HMG

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Research Organization:: Cornell Univ., Ithaca, NY (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); Swedish University of Agricultural Sciences; National Science Foundation (NSF); Agence nationale de la recherche (ANR)

Grant/Contract Number:: AC02-05CH11231; ANR-05-BLAN-0385; SWE-2005-453

OSTI ID:: 1627438

Journal Information:: PLoS ONE, Vol. 5, Issue 12; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
protein domains
protein structure prediction
protein structure
transcription factors
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