The information highways of a biotechnological workhorse – signal transduction in Hypocrea jecorina

Schmoll, Monika

doi:10.1186/1471-2164-9-430

Title: The information highways of a biotechnological workhorse – signal transduction in Hypocrea jecorina

Journal Article · Sat Sep 20 00:00:00 EDT 2008 · BMC Genomics

DOI:https://doi.org/10.1186/1471-2164-9-430· OSTI ID:1626468

Schmoll, Monika ^[1]

Vienna Univ. of Technology (Austria)

Background: The ascomycete Hypocrea jecorina (anamorph Trichoderma reesei) is one of the most prolific producers of biomass-degrading enzymes and frequently termed an industrial workhorse. To compete for nutrients in its habitat despite its shortcoming in certain degradative enzymes, efficient perception and interpretation of environmental signals is indispensable. A better understanding of these signals as well as their transmission machinery can provide sources for improvement of biotechnological processes. Results: The genome of H. jecorina was analysed for the presence and composition of common signal transduction pathways including heterotrimeric G-protein cascades, cAMP signaling, mitogen activated protein kinases, two component phosphorelay systems, proteins involved in circadian rhythmicity and light response, calcium signaling and the superfamily of Ras small GTPases. The results of this survey are discussed in the context of current knowledge in order to assess putative functions as well as potential impact of alterations of the respective pathways. Conclusion: Important findings include an additional, bacterial type phospholipase C protein and an additional 6-4 photolyase. Moreover the presence of 4 RGS-(Regulator of G-protein Signaling) proteins and 3 GprK-type G-protein coupled receptors comprising an RGS-domain suggest a more complex posttranslational regulation of G-protein signaling than in other ascomycetes. Also the finding, that H. jecorina, unlike yeast possesses class I phosducins which are involved in phototransduction in mammals warrants further investigation. An alteration in the regulation of circadian rhythmicity may be deduced from the extension of both the class I and II of casein kinases, homologues of which are implicated in phosphorylation of FRQ in Neurospora crassa. On the other hand, a shortage in the number of the pathogenicity related PTH11-type G-protein coupled receptors (GPCRs) as well as a lack of microbial opsins was detected. Considering its efficient enzyme system for breakdown of cellulosic materials, it came as a surprise that H. jecorina does not possess a carbon sensing GPCR.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; Austrian Science Fund (FWF)

Grant/Contract Number:: AC02-05CH11231; FWF P-17325

OSTI ID:: 1626468

Journal Information:: BMC Genomics, Vol. 9, Issue 1; ISSN 1471-2164

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

References (76)

Guanine nucleotide exchange factors: Activators of Ras superfamily proteins Overbeck, Ashley F.; Brtva, Teresa R.; Cox, Adrienne D. Molecular Reproduction and Development, Vol. 42, Issue 4 https://doi.org/10.1002/mrd.1080420415	journal	December 1995
Developmental and Photoregulation of al-1 and al-2, Structural Genes for Two Enzymes Essential for Carotenoid Biosynthesis in Neurospora Li, Changgong; Schmidhauser, Thomas J. Developmental Biology, Vol. 169, Issue 1 https://doi.org/10.1006/dbio.1995.1129	journal	May 1995
Light and Development Regulate the Expression of the Albino-3 Gene in Neurospora crassa Arpaia, Giuseppina; Carattoli, Alessandra; Macino, Giuseppe Developmental Biology, Vol. 170, Issue 2 https://doi.org/10.1006/dbio.1995.1242	journal	August 1995
Statistical properties of the ordinary least-squares, generalized least-squares, and minimum-evolution methods of phylogenetic inference Rzhetsky, Andrey; Nei, Masatoshi Journal of Molecular Evolution, Vol. 35, Issue 4 https://doi.org/10.1007/bf00161174	journal	October 1992
The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis Spröte, Petra; Brakhage, Axel A. Archives of Microbiology, Vol. 188, Issue 1 https://doi.org/10.1007/s00203-007-0224-y	journal	March 2007
Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa Banno, Shinpei; Noguchi, Rieko; Yamashita, Kazuhiro Current Genetics, Vol. 51, Issue 3 https://doi.org/10.1007/s00294-006-0116-8	journal	January 2007
The fungal opsin gene nop-1 is negatively-regulated by a component of the blue light sensing pathway and influences conidiation-specific gene expression in Neurospora crassa Bieszke, Jennifer A.; Li, Liande; Borkovich, Katherine A. Current Genetics, Vol. 52, Issue 3-4 https://doi.org/10.1007/s00294-007-0148-8	journal	August 2007
Heterotrimeric C proteins: Organizers of transmembrane signals Neer, Eva J. Cell, Vol. 80, Issue 2 https://doi.org/10.1016/0092-8674(95)90407-7	journal	January 1995
Production of recombinant proteins in the filamentous fungus Trichoderma reesei Keränen, Sirkka; Penttilä, Merja Current Opinion in Biotechnology, Vol. 6, Issue 5, p. 534-537 https://doi.org/10.1016/0958-1669(95)80088-3	journal	January 1995
Function of phosducin-like proteins in G protein signaling and chaperone-assisted protein folding Willardson, Barry M.; Howlett, Alyson C. Cellular Signalling, Vol. 19, Issue 12 https://doi.org/10.1016/j.cellsig.2007.06.013	journal	December 2007
The Aspergillus nidulans Phytochrome FphA Represses Sexual Development in Red Light Blumenstein, Anne; Vienken, Kay; Tasler, Ronja Current Biology, Vol. 15, Issue 20 https://doi.org/10.1016/j.cub.2005.08.061	journal	October 2005
Functional and Physical Interaction of Blue- and Red-Light Sensors in Aspergillus nidulans Purschwitz, Janina; Müller, Sylvia; Kastner, Christian Current Biology, Vol. 18, Issue 4 https://doi.org/10.1016/j.cub.2008.01.061	journal	February 2008
How fungi keep time: circadian system in Neurospora and other fungi Dunlap, Jay C.; Loros, Jennifer J. Current Opinion in Microbiology, Vol. 9, Issue 6 https://doi.org/10.1016/j.mib.2006.10.008	journal	December 2006
Directly from Gα to protein kinase A: the kelch repeat protein bypass of adenylate cyclase Peeters, T.; Versele, M.; Thevelein, J. Trends in Biochemical Sciences, Vol. 32, Issue 12 https://doi.org/10.1016/j.tibs.2007.09.011	journal	December 2007
MAP kinase pathways as regulators of fungal virulence Román, Elvira; Arana, David M.; Nombela, César Trends in Microbiology, Vol. 15, Issue 4 https://doi.org/10.1016/j.tim.2007.02.001	journal	April 2007
Coping with stress: calmodulin and calcineurin in model and pathogenic fungi Kraus, Peter R.; Heitman, Joseph Biochemical and Biophysical Research Communications, Vol. 311, Issue 4 https://doi.org/10.1016/s0006-291x(03)01528-6	journal	November 2003
Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins Broek, Daniel; Samiy, Nasrollah; Fasano, Ottavio Cell, Vol. 41, Issue 3 https://doi.org/10.1016/s0092-8674(85)80057-x	journal	July 1985
Ca2+-calmodulin antagonists interfere with xylanase formation and secretion in Trichoderma reesei Mach, Robert L.; Zeilinger, Susanne; Kristufek, Doris Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1403, Issue 3 https://doi.org/10.1016/s0167-4889(98)00068-8	journal	July 1998
Histidine kinases and response regulator proteins in two-component signaling systems West, Ann H.; Stock, Ann M. Trends in Biochemical Sciences, Vol. 26, Issue 6 https://doi.org/10.1016/s0968-0004(01)01852-7	journal	June 2001
A Eukaryotic Protein, NOP-1, Binds Retinal To Form an Archaeal Rhodopsin-like Photochemically Reactive Pigment ^† Bieszke, Jennifer A.; Spudich, Elena N.; Scott, Kenneth L. Biochemistry, Vol. 38, Issue 43 https://doi.org/10.1021/bi9916170	journal	October 1999
Adenylyl cyclases and the interaction between calcium and cAMP signalling Cooper, Dermot M. F.; Mons, Nicole; Karpen, Jeffrey W. Nature, Vol. 374, Issue 6521 https://doi.org/10.1038/374421a0	journal	March 1995
The genome sequence of the filamentous fungus Neurospora crassa Galagan, James E.; Calvo, Sarah E.; Borkovich, Katherine A. Nature, Vol. 422, Issue 6934 https://doi.org/10.1038/nature01554	journal	April 2003
Heterotrimeric G protein activation by G-protein-coupled receptors Oldham, William M.; Hamm, Heidi E. Nature Reviews Molecular Cell Biology, Vol. 9, Issue 1 https://doi.org/10.1038/nrm2299	journal	January 2008
Fungal photoreceptors: sensory molecules for fungal development and behaviour Corrochano, Luis M. Photochemical & Photobiological Sciences, Vol. 6, Issue 7 https://doi.org/10.1039/b702155k	journal	January 2007
cAMP and ras signalling independently control spore germination in the filamentous fungus Aspergillus nidulans Fillinger, Sabine; Chaveroche, Marie-Kim; Shimizu, Kiminori Molecular Microbiology, Vol. 44, Issue 4 https://doi.org/10.1046/j.1365-2958.2002.02933.x	journal	May 2002
Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK Vitalini, M. W.; de Paula, R. M.; Goldsmith, C. S. Proceedings of the National Academy of Sciences, Vol. 104, Issue 46 https://doi.org/10.1073/pnas.0704900104	journal	November 2007
Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex McLaughlin, J. N.; Thulin, C. D.; Hart, S. J. Proceedings of the National Academy of Sciences, Vol. 99, Issue 12 https://doi.org/10.1073/pnas.112075699	journal	June 2002
The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins Bieszke, J. A.; Braun, E. L.; Bean, L. E. Proceedings of the National Academy of Sciences, Vol. 96, Issue 14 https://doi.org/10.1073/pnas.96.14.8034	journal	July 1999
Rapid Blue Light Regulation of a Trichoderma harzianum Photolyase Gene Berrocal-Tito, Gloria; Sametz-Baron, Liat; Eichenberg, Klaus Journal of Biological Chemistry, Vol. 274, Issue 20 https://doi.org/10.1074/jbc.274.20.14288	journal	May 1999
Functional Analysis of Plp1 and Plp2, Two Homologues of Phosducin in Yeast Flanary, Paul L.; DiBello, Paul R.; Estrada, Paula Journal of Biological Chemistry, Vol. 275, Issue 24 https://doi.org/10.1074/jbc.m002163200	journal	June 2000
The Phytochromes, a Family of Red/Far-red Absorbing Photoreceptors Fankhauser, Christian Journal of Biological Chemistry, Vol. 276, Issue 15 https://doi.org/10.1074/jbc.r100006200	journal	February 2001
G proteins in Ustilago maydis: transmission of multiple signals? Regenfelder, E. The EMBO Journal, Vol. 16, Issue 8 https://doi.org/10.1093/emboj/16.8.1934	journal	April 1997
GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Gα subunit and functions in a Ras-independent pathway Xue, Yong; Batlle, Montserrat; Hirsch, Jeanne P. The EMBO Journal, Vol. 17, Issue 7 https://doi.org/10.1093/emboj/17.7.1996	journal	April 1998
VIVID is a flavoprotein and serves as a fungal blue light photoreceptor for photoadaptation Schwerdtfeger, C. The EMBO Journal, Vol. 22, Issue 18 https://doi.org/10.1093/emboj/cdg451	journal	September 2003
Pka, Ras and RGS Protein Interactions Regulate Activity of AflR, a Zn(II)2Cys6 Transcription Factor in Aspergillus nidulans Shimizu, Kiminori; Hicks, Julie K.; Huang, Tzu-Pi Genetics, Vol. 165, Issue 3 https://doi.org/10.1093/genetics/165.3.1095	journal	November 2003
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Altschul, Stephen F.; Madden, Thomas L.; Schäffer, Alejandro A. Nucleic Acids Research, Vol. 25, Issue 17, p. 3389-3402 https://doi.org/10.1093/nar/25.17.3389	journal	September 1997
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools Thompson, J. Nucleic Acids Research, Vol. 25, Issue 24 https://doi.org/10.1093/nar/25.24.4876	journal	December 1997
CDD: a curated Entrez database of conserved domain alignments Marchler-Bauer, A. Nucleic Acids Research, Vol. 31, Issue 1 https://doi.org/10.1093/nar/gkg087	journal	January 2003
The Database of Interacting Proteins: 2004 update Salwinski, L. Nucleic Acids Research, Vol. 32, Issue 90001 https://doi.org/10.1093/nar/gkh086	journal	January 2004
Enhanced responsiveness and sensitivity to blue light by blr-2 overexpression in Trichoderma atroviride Esquivel-Naranjo, E. U.; Herrera-Estrella, A. Microbiology, Vol. 153, Issue 11 https://doi.org/10.1099/mic.0.2007/007302-0	journal	November 2007
Novel light-regulated genes in Trichoderma atroviride: a dissection by cDNA microarrays Rosales-Saavedra, T.; Esquivel-Naranjo, E. U.; Casas-Flores, S. Microbiology, Vol. 152, Issue 11 https://doi.org/10.1099/mic.0.29000-0	journal	November 2006
MAP kinase and cAMP signaling regulate infection structure formation and pathogenic growth in the rice blast fungus Magnaporthe grisea. Xu, J. R.; Hamer, J. E. Genes & Development, Vol. 10, Issue 21 https://doi.org/10.1101/gad.10.21.2696	journal	November 1996
Calcium at the Crossroads of Signaling Sanders, Dale; Pelloux, Jérôme; Brownlee, Colin The Plant Cell, Vol. 14, Issue suppl 1 https://doi.org/10.1105/tpc.002899	journal	May 2002
Magnaporthe grisea Pth11p Is a Novel Plasma Membrane Protein That Mediates Appressorium Differentiation in Response to Inductive Substrate Cues DeZwaan, Todd M.; Carroll, Anne M.; Valent, Barbara The Plant Cell, Vol. 11, Issue 10 https://doi.org/10.1105/tpc.11.10.2013	journal	October 1999
Fermentable sugars and intracellular acidification as specific activators of the RAS-adenylate cyclase signalling pathway in yeast: the relationship to nutrient-induced cell cycle control Thevelein, J. M. Molecular Microbiology, Vol. 5, Issue 6 https://doi.org/10.1111/j.1365-2958.1991.tb00776.x	journal	June 1991
A role for creD, a carbon catabolite repression gene from Aspergillus nidulans, in ubiquitination Boase, Natasha A.; Kelly, Joan M. Molecular Microbiology, Vol. 53, Issue 3 https://doi.org/10.1111/j.1365-2958.2004.04172.x	journal	June 2004
Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization Kohout, Trudy A.; Lefkowitz, Robert J. Molecular Pharmacology, Vol. 63, Issue 1 https://doi.org/10.1124/mol.63.1.9	journal	January 2003
Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling Hollinger, S. Pharmacological Reviews, Vol. 54, Issue 3 https://doi.org/10.1124/pr.54.3.527	journal	September 2002
The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization Cuomo, C. A.; Guldener, U.; Xu, J. -R. Science, Vol. 317, Issue 5843 https://doi.org/10.1126/science.1143708	journal	September 2007
Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock Griffin Jr., E. A. Science, Vol. 286, Issue 5440 https://doi.org/10.1126/science.286.5440.768	journal	October 1999
Osmoregulation and Fungicide Resistance: the Neurospora crassa os-2 Gene Encodes a HOG1 Mitogen-Activated Protein Kinase Homologue Zhang, Y.; Lamm, R.; Pillonel, C. Applied and Environmental Microbiology, Vol. 68, Issue 2 https://doi.org/10.1128/aem.68.2.532-538.2002	journal	February 2002
Trichoderma Mitogen-Activated Protein Kinase Signaling Is Involved in Induction of Plant Systemic Resistance Viterbo, Ada; Harel, Michal; Horwitz, Benjamin A. Applied and Environmental Microbiology, Vol. 71, Issue 10 https://doi.org/10.1128/aem.71.10.6241-6246.2005	journal	October 2005
Signal Transduction by Tga3, a Novel G Protein Subunit of Trichoderma atroviride Zeilinger, S.; Reithner, B.; Scala, V. Applied and Environmental Microbiology, Vol. 71, Issue 3 https://doi.org/10.1128/aem.71.3.1591-1597.2005	journal	March 2005
Trichoderma atroviride PHR1, a Fungal Photolyase Responsible for DNA Repair, Autoregulates Its Own Photoinduction Berrocal-Tito, Gloria M.; Esquivel-Naranjo, Edgardo U.; Horwitz, Benjamin A. Eukaryotic Cell, Vol. 6, Issue 9 https://doi.org/10.1128/ec.00208-06	journal	September 2007
Trichoderma atroviride G-Protein α-Subunit Gene tga1 Is Involved in Mycoparasitic Coiling and Conidiation Rocha-Ramírez, Víctor; Omero, Carmi; Chet, Ilan Eukaryotic Cell, Vol. 1, Issue 4 https://doi.org/10.1128/ec.1.4.594-605.2002	journal	August 2002
TmkA, a Mitogen-Activated Protein Kinase of Trichoderma virens , Is Involved in Biocontrol Properties and Repression of Conidiation in the Dark Mukherjee, Prasun K.; Latha, Jagannathan; Hadar, Ruthi Eukaryotic Cell, Vol. 2, Issue 3 https://doi.org/10.1128/ec.2.3.446-455.2003	journal	June 2003
Whole-Genome Analysis of Two-Component Signal Transduction Genes in Fungal Pathogens Catlett, Natalie L.; Yoder, Olen C.; Turgeon, B. Gillian Eukaryotic Cell, Vol. 2, Issue 6 https://doi.org/10.1128/ec.2.6.1151-1161.2003	journal	December 2003
Role of a Mitogen-Activated Protein Kinase Pathway during Conidial Germination and Hyphal Fusion in Neurospora crassa Pandey, Amita; Roca, M. Gabriela; Read, Nick D. Eukaryotic Cell, Vol. 3, Issue 2 https://doi.org/10.1128/ec.3.2.348-358.2004	journal	April 2004
Group III Histidine Kinase Is a Positive Regulator of Hog1-Type Mitogen-Activated Protein Kinase in Filamentous Fungi Yoshimi, Akira; Kojima, Kaihei; Takano, Yoshitaka Eukaryotic Cell, Vol. 4, Issue 11 https://doi.org/10.1128/ec.4.11.1820-1828.2005	journal	November 2005
Genetic and Molecular Analysis of Phytochromes from the Filamentous Fungus Neurospora crassa Froehlich, Allan C.; Noh, Bosl; Vierstra, Richard D. Eukaryotic Cell, Vol. 4, Issue 12 https://doi.org/10.1128/ec.4.12.2140-2152.2005	journal	December 2005
The Phosducin-Like Protein PhnA Is Required for Gβγ-Mediated Signaling for Vegetative Growth, Developmental Control, and Toxin Biosynthesis in Aspergillus nidulans Seo, Jeong-Ah; Yu, Jae-Hyuk Eukaryotic Cell, Vol. 5, Issue 2 https://doi.org/10.1128/ec.5.2.400-410.2006	journal	February 2006
Cross Talk between a Fungal Blue-Light Perception System and the Cyclic AMP Signaling Pathway Casas-Flores, Sergio; Rios-Momberg, Mauricio; Rosales-Saavedra, Teresa Eukaryotic Cell, Vol. 5, Issue 3 https://doi.org/10.1128/ec.5.3.499-506.2006	journal	March 2006
Developmental Decisions in Aspergillus nidulans Are Modulated by Ras Activity Som, Tapan; Kolaparthi, Venkata S. R. Molecular and Cellular Biology, Vol. 14, Issue 8 https://doi.org/10.1128/mcb.14.8.5333-5348.1994	journal	August 1994
Cla4p, a Saccharomyces cerevisiae Cdc42p-Activated Kinase Involved in Cytokinesis, Is Activated at Mitosis† Benton, Benjamin K.; Tinkelenberg, Arthur; Gonzalez, Isabel Molecular and Cellular Biology, Vol. 17, Issue 9 https://doi.org/10.1128/mcb.17.9.5067	journal	September 1997
Signal Transduction Cascades Regulating Fungal Development and Virulence Lengeler, K. B.; Davidson, R. C.; D'souza, C. Microbiology and Molecular Biology Reviews, Vol. 64, Issue 4 https://doi.org/10.1128/mmbr.64.4.746-785.2000	journal	December 2000
Cell Wall Integrity Signaling in Saccharomyces cerevisiae Levin, D. E. Microbiology and Molecular Biology Reviews, Vol. 69, Issue 2 https://doi.org/10.1128/mmbr.69.2.262-291.2005	journal	June 2005
Adenosine 3',5'-phosphate in fungi Pall, M. L. Microbiological Reviews, Vol. 45, Issue 3 https://doi.org/10.1128/mr.45.3.462-480.1981	journal	September 1981
Metabolic regulation of endoglucanase synthesis in Trichoderma reesei : participation of cyclic AMP and glucose-6-phosphate Šesták, Sergej; Farkaš, Vladimír Canadian Journal of Microbiology, Vol. 39, Issue 3 https://doi.org/10.1139/m93-048	journal	March 1993
Biology of the p21-Activated Kinases Bokoch, Gary M. Annual Review of Biochemistry, Vol. 72, Issue 1 https://doi.org/10.1146/annurev.biochem.72.121801.161742	journal	June 2003
Role of phosphoinositides in transmembrane signaling. Rana, R. S.; Hokin, L. E. Physiological Reviews, Vol. 70, Issue 1 https://doi.org/10.1152/physrev.1990.70.1.115	journal	January 1990
The Neurospora Circadian System Dunlap, Jay C.; Loros, Jennifer J. Journal of Biological Rhythms, Vol. 19, Issue 5 https://doi.org/10.1177/0748730404269116	journal	October 2004
Impact of light on Hypocrea jecorina and the multiple cellular roles of ENVOY in this process Schuster, Andrè; Kubicek, Christian P.; Friedl, Martina A. BMC Genomics, Vol. 8, Issue 1 https://doi.org/10.1186/1471-2164-8-449	journal	January 2007
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals Luttrell, Louis M.; Lefkowitz, Robert J. Journal of Cell Science, Vol. 115, Issue 3 https://doi.org/10.1242/jcs.115.3.455	journal	February 2002
Characterization of the NikA Histidine Kinase Implicated in the Phosphorelay Signal Transduction of Aspergillus nidulans , with Special Reference to Fungicide Responses Hagiwara, Daisuke; Matsubayashi, Yoshihiro; Marui, Junichiro Bioscience, Biotechnology, and Biochemistry, Vol. 71, Issue 3 https://doi.org/10.1271/bbb.70051	journal	March 2007
GFP-Tagged Expression Analysis Revealed That Some Histidine Kinases ofAspergillus nidulansShow Temporally and Spatially Different Expression during the Life Cycle Suzuki, Asako; Kanamaru, Kyoko; Azuma, Nobuhiro Bioscience, Biotechnology, and Biochemistry, Vol. 72, Issue 2 https://doi.org/10.1271/bbb.70543	journal	February 2008
A Mitogen-Activated Protein Kinase Pathway Essential for Mating and Contributing to Vegetative Growth in Neurospora crassa Li, Dan; Bobrowicz, Piotr; Wilkinson, Heather H. Genetics, Vol. 170, Issue 3 https://doi.org/10.1534/genetics.104.036772	journal	March 2005

Cited By (18)

The Duality of the MAPK Signaling Pathway in the Control of Metabolic Processes and Cellulase Production in Trichoderma reesei de Paula, Renato Graciano; Antoniêto, Amanda Cristina Campos; Carraro, Cláudia Batista Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-33383-1	journal	October 2018
RNA-sequencing reveals the complexities of the transcriptional response to lignocellulosic biofuel substrates in Aspergillus niger Pullan, Steven T.; Daly, Paul; Delmas, Stéphane Fungal Biology and Biotechnology, Vol. 1, Issue 1 https://doi.org/10.1186/s40694-014-0003-x	journal	November 2014
Trichoderma: the genomics of opportunistic success Druzhinina, Irina S.; Seidl-Seiboth, Verena; Herrera-Estrella, Alfredo Nature Reviews Microbiology, Vol. 9, Issue 10 https://doi.org/10.1038/nrmicro2637	journal	September 2011
N,N-dimethylformamide induces cellulase production in the filamentous fungus Trichoderma reesei Chen, Yumeng; Wu, Chuan; Shen, Yaling Biotechnology for Biofuels, Vol. 12, Issue 1 https://doi.org/10.1186/s13068-019-1375-1	journal	February 2019
Identification of the role of a MAP kinase Tmk2 in Hypocrea jecorina (Trichoderma reesei) Wang, Mingyu; Dong, Yanmei; Zhao, Qiushuang Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep06732	journal	October 2014
The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei Tisch, Doris; Kubicek, Christian P.; Schmoll, Monika BMC Genomics, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2164-12-613	journal	December 2011
Extracellular ATP activates MAPK and ROS signaling during injury response in the fungus Trichoderma atroviride Medina-Castellanos, Elizabeth; Esquivel-Naranjo, Edgardo U.; Heil, Martin Frontiers in Plant Science, Vol. 5 https://doi.org/10.3389/fpls.2014.00659	journal	November 2014
Correlation of gene expression and protein production rate - a system wide study Arvas, Mikko; Pakula, Tiina; Smit, Bart BMC Genomics, Vol. 12, Issue 1 https://doi.org/10.1186/1471-2164-12-616	journal	December 2011
Comparative analysis of the repertoire of G protein-coupled receptors of three species of the fungal genus Trichoderma Gruber, Sabine; Omann, Markus; Zeilinger, Susanne BMC Microbiology, Vol. 13, Issue 1 https://doi.org/10.1186/1471-2180-13-108	journal	January 2013
ENVOY Is a Major Determinant in Regulation of Sexual Development in Hypocrea jecorina ( Trichoderma reesei ) Seibel, Christian; Tisch, Doris; Kubicek, Christian P. Eukaryotic Cell, Vol. 11, Issue 7 https://doi.org/10.1128/ec.05321-11	journal	May 2012
Biology and biotechnology of Trichoderma Schuster, André; Schmoll, Monika Applied Microbiology and Biotechnology, Vol. 87, Issue 3 https://doi.org/10.1007/s00253-010-2632-1	journal	May 2010
New Genomic Approaches to Enhance Biomass Degradation by the Industrial Fungus Trichoderma reesei de Paula, Renato Graciano; Antoniêto, Amanda Cristina Campos; Ribeiro, Liliane Fraga Costa International Journal of Genomics, Vol. 2018 https://doi.org/10.1155/2018/1974151	journal	September 2018
Role of Trichoderma reesei mitogen-activated protein kinases (MAPKs) in cellulase formation Wang, Mingyu; Zhang, Meiling; Li, Ling Biotechnology for Biofuels, Vol. 10, Issue 1 https://doi.org/10.1186/s13068-017-0789-x	journal	April 2017
Functional Genomic Analysis of Aspergillus flavus Interacting with Resistant and Susceptible Peanut Wang, Houmiao; Lei, Yong; Yan, Liying Toxins, Vol. 8, Issue 2 https://doi.org/10.3390/toxins8020046	journal	February 2016
Trichoderma in the light of day – Physiology and development Schmoll, Monika; Esquivel-Naranjo, Edgardo Ulises; Herrera-Estrella, Alfredo Fungal Genetics and Biology, Vol. 47, Issue 11 https://doi.org/10.1016/j.fgb.2010.04.010	journal	November 2010
New insights into the mechanism of light modulated signaling by heterotrimeric G-proteins: ENVOY acts on gna1 and gna3 and adjusts cAMP levels in Trichoderma reesei (Hypocrea jecorina) Tisch, Doris; Kubicek, Christian P.; Schmoll, Monika Fungal Genetics and Biology, Vol. 48, Issue 6 https://doi.org/10.1016/j.fgb.2010.12.009	journal	June 2011
The role of pheromone receptors for communication and mating in Hypocrea jecorina (Trichoderma reesei) Seibel, Christian; Tisch, Doris; Kubicek, Christian P. Fungal Genetics and Biology, Vol. 49, Issue 10 https://doi.org/10.1016/j.fgb.2012.07.004	journal	October 2012
A Mitogen-Activated Protein Kinase Tmk3 Participates in High Osmolarity Resistance, Cell Wall Integrity Maintenance and Cellulase Production Regulation in Trichoderma reesei Wang, Mingyu; Zhao, Qiushuang; Yang, Jinghua PLoS ONE, Vol. 8, Issue 8 https://doi.org/10.1371/journal.pone.0072189	journal	August 2013

Similar Records

Light-dependent roles of the G-protein α subunit GNA1 of Hypocrea jecorina (anamorph Trichoderma reesei)

Journal Article · Thu Sep 03 00:00:00 EDT 2009 · BMC Biology · OSTI ID:1626468

Seibel, Christian; Gremel, Gabriela; do Nascimento Silva, Roberto; +3 more

The Hypocrea jecorina (Trichoderma reesei) hypercellulolytic mutant RUT C30 lacks a 85 kb (29 gene-encoding) region of the wild-type genome

Journal Article · Fri Jul 11 00:00:00 EDT 2008 · BMC Genomics · OSTI ID:1626468

Seidl, Verena; Gamauf, Christian; Druzhinina, Irina S.; +3 more

Impact of light on Hypocrea jecorina and the multiple cellular roles of ENVOY in this process

Journal Article · Tue Dec 04 00:00:00 EST 2007 · BMC Genomics · OSTI ID:1626468

Schuster, Andrè; Kubicek, Christian P.; Friedl, Martina A.; +2 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
biotechnology & applied microbiology
genetics & heredity
filamentous fungus
casein kinase
light response
histidine kinase
cellulase gene expression

Title: The information highways of a biotechnological workhorse – signal transduction in Hypocrea jecorina

Citation Formats

References (76)

Cited By (18)

Similar Records

Related Subjects