Sulphur metabolism and cellulase gene expression are connected processes in the filamentous fungus Hypocrea jecorina (anamorph Trichoderma reesei)

Gremel, Gabriela; Dorrer, Marcel; Schmoll, Monika

doi:10.1186/1471-2180-8-174

Sulphur metabolism and cellulase gene expression are connected processes in the filamentous fungus Hypocrea jecorina (anamorph Trichoderma reesei)

Journal Article · Wed Oct 08 00:00:00 EDT 2008 · BMC Microbiology

DOI:https://doi.org/10.1186/1471-2180-8-174· OSTI ID:1626494

Gremel, Gabriela ^[1]; Dorrer, Marcel ^[2]; Schmoll, Monika ^[2]

Vienna Univ. of Technology (Austria). Inst. of Chemical Engineering. Research Area of Gene Technology and Applied Biochemistry; DOE/OSTI
Vienna Univ. of Technology (Austria). Inst. of Chemical Engineering. Research Area of Gene Technology and Applied Biochemistry

Background: Sulphur compounds like cysteine, methionine and S-adenosylmethionine are essential for the viability of most cells. Thus many organisms have developed a complex regulatory circuit that governs the expression of enzymes involved in sulphur assimilation and metabolism. In the filamentous fungus Hypocrea jecorina (anamorph Trichoderma reesei) little is known about the participants in this circuit. Results: Analyses of proteins binding to the cellulase activating element (CAE) within the promotor of the cellobiohydrolase cbh2 gene led to the identification of a putative E3 ubiquitin ligase protein named LIMPET (LIM1), which is an orthologue of the sulphur regulators SCON-2 of Neurospora crassa and Met30p of Saccharomyces cerevisiae. Transcription of lim1 is specifically upregulated upon sulphur limitation and responds to cellulase inducing conditions. In addition, light dependent stimulation/shut down of cellulase gene transcription by methionine in the presence of sulphate was observed. Further, lim1 transcriptionally reacts to a switch from constant darkness to constant light and is subject to regulation by the light regulatory protein ENVOY. Thus lim1, despite its function in sulphur metabolite repression, responds both to light as well as sulphur- and carbon source. Upon growth on cellulose, the uptake of sulphate is dependent on the light status and essential for growth in light. Unlike other fungi, growth of H. jecorina is not inhibited by selenate under low sulphur conditions, suggesting altered regulation of sulphur metabolism. Phylogenetic analysis of the five sulphate permeases found in the genome of H. jecorina revealed that the predominantly mycelial sulphate permease is lacking, thus supporting this hypothesis. Conclusion: Our data indicate that the significance of the sulphate/methionine-related signal with respect to cellulase gene expression is dependent on the light status and reaches beyond detection of sulphur availability.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC)

Sponsoring Organization:: Australian Science Fund (FWF); USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1626494

Journal Information:: BMC Microbiology, Journal Name: BMC Microbiology Journal Issue: 1 Vol. 8; ISSN 1471-2180

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Regulation of plant cell wall degradation by light in Trichoderma Schmoll, Monika Fungal Biology and Biotechnology, Vol. 5, Issue 1 https://doi.org/10.1186/s40694-018-0052-7	journal	April 2018
The Promoter Toolbox for Recombinant Gene Expression in Trichoderma reesei Fitz, Elisabeth; Wanka, Franziska; Seiboth, Bernhard Frontiers in Bioengineering and Biotechnology, Vol. 6 https://doi.org/10.3389/fbioe.2018.00135	journal	October 2018
Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition in Neurospora crassa Horta, Maria Augusta C.; Thieme, Nils; Gao, Yuqian Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02317	journal	November 2019

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59 BASIC BIOLOGICAL SCIENCES
cellulase
cullulase gene
microbiology
sulphate uptake
sulphur metabolism
sulphur source

Sulphur metabolism and cellulase gene expression are connected processes in the filamentous fungus Hypocrea jecorina (anamorph Trichoderma reesei)

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