A novel approach to the microdosimetry of neutron capture therapy. Part I. High-resolution quantitative autoradiography applied to microdosimetry in neutron capture therapy
- Tufts Univ. School of Medicine, Boston, MA (United States)
A novel approach to the microdosimetry of neutron capture therapy has been developed using high-resolution quantitative autoradiography (HRQAR) and two-dimensional Monte Carlo simulation. This approach has been applied using actual cell morophology (nuclear and cytoplasmic cell structures) and the measured microdistribution of boron-10 in a transplanted murine brain tumor (GL261) containing p-boronophenylalanine (BPA) as the boron compound. The 2D Monte Carlo transport code for the {alpha} and {sup 7}Li charged particles from the {sup 10}B(n,{alpha}){sup 7}Li reactions has been developed as a surrogate to a full 3D approach to calculate a variety of different microdosimetric parameters. The HRQAR method and the surrogate 2D Monte Carlo approach are described in detail and examples of their use are presented. 27 refs., 11 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 161584
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 144; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
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