Microdosimetry for Boron Neutron Capture Therapy

Technical Report · Tue Sep 05 04:00:00 EDT 2000

DOI:https://doi.org/10.2172/770637· OSTI ID:770637

Maughan, R L ^[1]; Kota, C

---

1. University of Pennsylvania

The specific aims of the research proposal were as follows: (1) To design and construct small volume tissue equivalent proportional counters for the dosimetry and microdosimetry of high intensity thermal and epithermal neutron beams used in BNCT, and of modified fast neutron beams designed for boron neutron capture enhanced fast neutron therapy (BNCEFNT). (2) To develop analytical methods for estimating the biological effectiveness of the absorbed dose in BNCT and BNCEFNT based on the measured microdosimetric spectra. (3) To develop an analytical framework for comparing the biological effectiveness of different epithermal neutron beams used in BNCT and BNCEFNT, based on correlated sets of measured microdosimetric spectra and radiobiological data. Specific aims (1) and (2) were achieved in their entirety and are comprehensively documented in Jay Burmeister's Ph.D. dissertation entitled ''Specification of physical and biologically effective absorbed dose in radiation therapies utilizing the boron neutron capture reaction'' (Wayne State University, 1999). Specific aim (3) proved difficult to accomplish because of a lack of sufficient radiobiological data.

• Research Organization: Wayne State Univ., Detroit, MI (US)
• Sponsoring Organization: USDOE Office of Energy Research (ER) (US)
• DOE Contract Number: FG02-96ER62217
• OSTI ID: 770637
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BORON
BORON NEUTRON CAPTURE THERAPY
DESIGN
EPITHERMAL NEUTRONS
FABRICATION
FAST NEUTRONS
MICRODOSIMETRY
NEUTRON CAPTURE THERAPY
NEUTRON REACTIONS
PROPORTIONAL COUNTERS
RADIATION DOSES
RADIOBIOLOGICAL EFFECTIVENESS