Mechanisms of lipid droplet biogenesis

Chapman, Kent D.; Aziz, Mina; Dyer, John M.; Mullen, Robert T.

doi:10.1042/bcj20180021

Mechanisms of lipid droplet biogenesis

Journal Article · Tue Jul 09 04:00:00 EDT 2019 · Biochemical Journal

DOI:https://doi.org/10.1042/bcj20180021· OSTI ID:1610446

^[1]; Aziz, Mina ^[2]; Dyer, John M. ^[3]; Mullen, Robert T. ^[4]

Department of Biological Sciences, BioDiscovery Institute, University of North Texas, Denton, TX, U.S.A.; DOE/OSTI
Department of Biological Sciences, BioDiscovery Institute, University of North Texas, Denton, TX, U.S.A.
USDA-ARS, US Arid-Land Agricultural Research Center, Maricopa, AZ, U.S.A.
Department of Molecular Cell Biology, University of Guelph, Guelph, Ontario, Canada

Abstract

Lipid droplets (LDs) are organelles that compartmentalize nonbilayer-forming lipids in the aqueous cytoplasm of cells. They are ubiquitous in most organisms, including in animals, protists, plants and microorganisms. In eukaryotes, LDs are believed to be derived by a budding and scission process from the surface of the endoplasmic reticulum, and this occurs concomitantly with the accumulation of neutral lipids, most often triacylglycerols and steryl esters. Overall, the mechanisms underlying LD biogenesis are difficult to generalize, in part because of the involvement of different sets of both evolutionarily conserved and organism-specific LD-packaging proteins. Here, we briefly compare and contrast these proteins and the allied processes responsible for LD biogenesis in cells of animals, yeasts and plants.

Research Organization:: Univ. of North Texas, Denton, TX (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

DOE Contract Number:: SC0000797; SC0016536

OSTI ID:: 1610446

Journal Information:: Biochemical Journal, Journal Name: Biochemical Journal Journal Issue: 13 Vol. 476; ISSN 0264-6021

Publisher:: Biochemical Society

Country of Publication:: United States

Language:: English

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