The physics of irradiation of biological matter by ion beams

Journal Article · Sun May 19 00:00:00 EDT 2019 · Radiation Physics and Chemistry (1993)

DOI:https://doi.org/10.1016/j.radphyschem.2019.05.027· OSTI ID:1529309

Quinto, M. A. ^[1]; Monti, J. M. ^[1]; Tachino, C. A. ^[1]; Weck, P. F. ^[2]; Fojón, O. A. ^[1]; Champion, C. ^[3]; Rivarola, R. D. ^[1]

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1. Instituto de Física Rosario (CONICET-UNR), Rosario (Argentina)
2. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
3. Bordeaux Univ., (France)

In radiobiology, predicting the evolution of irradiated biological matter is nowadays an active field of research to identify DNA lesions or to adapt the radiotherapeutic protocols in radiation oncology. In this context, the numerical methods, based on Monte Carlo track-structure simulations, represent the most suitable and powerful tools for understanding the radiobiological damages induced by ionizing particles. Here, we report the theoretical differential and total cross sections, computed within the quantum mechanical continuum distorted wave-eikonal initial state (CDW-EIS) method, for ion impact on water vapor and DNA nucleobases. These cross sections have been used to build up the input database for the homemade Monte Carlo track-structure TILDA-V. A comparison between the theoretical predictions and the available experimental data is presented. Micro-dosimetry results obtained with TILDA-V are also reported.

• Research Organization: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA)
• Grant/Contract Number: AC04-94AL85000; NA0003525
• OSTI ID: 1529309
• Alternate ID(s): OSTI ID: 1701868
• Report Number(s): SAND--2018-14322J; 671069
• Journal Information: Radiation Physics and Chemistry (1993), Journal Name: Radiation Physics and Chemistry (1993) Journal Issue: C Vol. 167; ISSN 0969-806X
• Publisher: Elsevier
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
Biological matter
Ions beams
Monte Carlo