A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

Whiting, Joshua J.; Myers, Edward; Manginell, Ronald P.; Moorman, Mathew W.; Anderson, John; Fix, Cory S.; Washburn, Cody; Staton, Al; Porter, Daniel; Graf, Darin; Wheeler, David R.; Howell, Stephen; Richards, John; Monteith, Haley; Achyuthan, Komandoor E.; Roukes, Michael; Simonson, Robert J.

doi:10.1039/C9LC00027E

A high-speed, high-performance, microfabricated comprehensive two-dimensional gas chromatograph

Journal Article · Mon Mar 18 00:00:00 EDT 2019 · Lab on a Chip

DOI:https://doi.org/10.1039/C9LC00027E· OSTI ID:1507410

Whiting, Joshua J. ^[1]; Myers, Edward ^[2]; Manginell, Ronald P. ^[1]; Moorman, Mathew W. ^[1]; Anderson, John ^[1]; Fix, Cory S. ^[1]; Washburn, Cody ^[1]; Staton, Al ^[1]; ^[1]; Graf, Darin ^[1]; Wheeler, David R. ^[1]; Howell, Stephen ^[1]; Richards, John ^[1]; Monteith, Haley ^[1]; ^[1]; Roukes, Michael ^[2]; Simonson, Robert J. ^[1]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
California Inst. of Technology (CalTech), Pasadena, CA (United States)

A small, consumable-free, low-power, ultra-high-speed comprehensive GC×GC system consisting of microfabricated columns, nanoelectromechanical system (NEMS) cantilever resonators for detection, and a valve-based stop-flow modulator is demonstrated. The separation of a highly polar 29-component mixture covering a boiling point range of 46 to 253 °C on a pair of microfabricated columns using a Staiger valve manifold in less than 7 seconds, and just over 4 seconds after the ensemble holdup time is demonstrated with a downstream FID. The analysis time of the second dimension was 160 ms, and peak widths in the second dimension range from 10–60 ms. A peak capacity of just over 300 was calculated for a separation of just over 6 s. Data from a continuous operation testing over 40 days and 20 000 runs of the GC×GC columns with the NEMS resonators using a 4-component test set is presented. As a result, the GC×GC-NEMS resonator system generated second-dimension peak widths as narrow as 8 ms with no discernable peak distortion due to under-sampling from the detector.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: DARPA Micro Gas Analyzer; USDOE

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1507410

Alternate ID(s):: OSTI ID: 1503725

Report Number(s):: SAND--2019-3452J; 673864

Journal Information:: Lab on a Chip, Journal Name: Lab on a Chip Journal Issue: 9 Vol. 19; ISSN LCAHAM; ISSN 1473-0197

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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