Automated two-dimensional interface for capillary gas chromatography

Patent · Tue Feb 20 04:00:00 EST 1996

OSTI ID:870301

Strunk, Michael R ^[1]; Bechtold, William E ^[1]

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1. Albuquerque, NM

A multidimensional gas chromatograph (GC) system having wide bore capillary and narrow bore capillary GC columns in series and having a novel system interface. Heart cuts from a high flow rate sample, separated by a wide bore GC column, are collected and directed to a narrow bore GC column with carrier gas injected at a lower flow compatible with a mass spectrometer. A bimodal six-way valve is connected with the wide bore GC column outlet and a bimodal four-way valve is connected with the narrow bore GC column inlet. A trapping and retaining circuit with a cold trap is connected with the six-way valve and a transfer circuit interconnects the two valves. The six-way valve is manipulated between first and second mode positions to collect analyte, and the four-way valve is manipulated between third and fourth mode positions to allow carrier gas to sweep analyte from a deactivated cold trap, through the transfer circuit, and then to the narrow bore GC capillary column for separation and subsequent analysis by a mass spectrometer. Rotary valves have substantially the same bore width as their associated columns to minimize flow irregularities and resulting sample peak deterioration. The rotary valves are heated separately from the GC columns to avoid temperature lag and resulting sample deterioration.

• Research Organization: LOVELACE BIOMED & ENV RES INST
• DOE Contract Number: AC04-76EV01013
• Assignee: Lovelace Biomedical & Environmental Research Institute, Inc. (Albuquerque, NM)
• Patent Number(s): US 5492555
• Application Number: 08/257,388
• OSTI ID: 870301
• Country of Publication: United States
• Language: English

Related Subjects

/95/73/96/
allow
analysis
analyte
associated
automated
avoid
bimodal
bore
bore capillary
capillary
capillary column
capillary gas
capillary gc
carrier
carrier gas
chromatograph
chromatography
circuit
cold
cold trap
collect
collected
column
columns
compatible
connected
cuts
deactivated
deterioration
directed
flow
flow rate
four-way
fourth
gas
gas chromatograph
gas chromatography
gas injected
gc
heart
heated
injected
inlet
interconnects
interface
irregularities
lag
manipulated
mass
mass spectrometer
minimize
mode
multidimensional
narrow
narrow bore
novel
outlet
peak
positions
rate
resulting
retaining
rotary
rotary valve
rotary valves
sample
separated
separately
separation
series
six-way
spectrometer
subsequent
subsequent analysis
substantially
sweep
temperature
third
transfer
transfer circuit
trap
trapping
two-dimensional
valve
valves
wide
width