Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials

Zhang, Tong; Gaffrey, Matthew J.; Thrall, Brian D.; Qian, Wei-Jun

doi:10.1007/s00216-018-1168-6

Mass spectrometry-based proteomics for system-level characterization of biological responses to engineered nanomaterials

Journal Article · Fri Jun 08 04:00:00 EDT 2018 · Analytical and Bioanalytical Chemistry

DOI:https://doi.org/10.1007/s00216-018-1168-6· OSTI ID:1503587

Zhang, Tong; Gaffrey, Matthew J.; Thrall, Brian D.;

The widespread applications of engineered nanomaterials or nanotechnology make the characterization of biological responses to nanomaterials as an important area of research. The applications of omics-based approaches such as mass spectrometry-based proteomics have revealed new insights into the cellular responses upon exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. For instance, a redox-dependent response is often associated with exposure of nanomaterials, which leads to the generation of reactive oxygen species. In this review, we discuss the general quantitative proteomics approaches, with an emphasis on redox proteomics and their applications for characterizing the biological responses to nanomaterials.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1503587

Report Number(s):: PNNL-SA-133275

Journal Information:: Analytical and Bioanalytical Chemistry, Journal Name: Analytical and Bioanalytical Chemistry Journal Issue: 24 Vol. 410; ISSN 1618-2642

Publisher:: Springer

Country of Publication:: United States

Language:: English

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