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Title: Advances in understanding paternally transmitted Chromosomal Abnormalities

Abstract

Multicolor FISH has been adapted for detecting the major types of chromosomal abnormalities in human sperm including aneuploidies for clinically-relevant chromosomes, chromosomal aberrations including breaks and rearrangements, and other numerical abnormalities. The various sperm FISH assays have been used to evaluate healthy men, men of advanced age, and men who have received mutagenic cancer therapy. The mouse has also been used as a model to investigate the mechanism of paternally transmitted genetic damage. Sperm FISH for the mouse has been used to detect chromosomally abnormal mouse sperm, while the PAINT/DAPI analysis of mouse zygotes has been used to evaluate the types of chromosomal defects that can be paternally transmitted to the embryo and their effects on embryonic development.

Authors:
; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab., CA (US)
Sponsoring Org.:
US Department of Energy (US)
OSTI Identifier:
15005287
Report Number(s):
UCRL-JC-143264
TRN: US200322%%354
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Conference
Resource Relation:
Conference: Teplice Program, Prachatice Conference, Prachatice (CZ), 09/03/2001--09/05/2001; Other Information: PBD: 1 Mar 2001
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; CHROMOSOMAL ABERRATIONS; CHROMOSOMES; DEFECTS; EMBRYOS; GENETICS; NEOPLASMS; ONTOGENESIS; SPERMATOZOA; THERAPY; ZYGOTES

Citation Formats

Marchetti, F, Sloter, E, and Wyrobek, A J. Advances in understanding paternally transmitted Chromosomal Abnormalities. United States: N. p., 2001. Web.
Marchetti, F, Sloter, E, & Wyrobek, A J. Advances in understanding paternally transmitted Chromosomal Abnormalities. United States.
Marchetti, F, Sloter, E, and Wyrobek, A J. Thu . "Advances in understanding paternally transmitted Chromosomal Abnormalities". United States. https://www.osti.gov/servlets/purl/15005287.
@article{osti_15005287,
title = {Advances in understanding paternally transmitted Chromosomal Abnormalities},
author = {Marchetti, F and Sloter, E and Wyrobek, A J},
abstractNote = {Multicolor FISH has been adapted for detecting the major types of chromosomal abnormalities in human sperm including aneuploidies for clinically-relevant chromosomes, chromosomal aberrations including breaks and rearrangements, and other numerical abnormalities. The various sperm FISH assays have been used to evaluate healthy men, men of advanced age, and men who have received mutagenic cancer therapy. The mouse has also been used as a model to investigate the mechanism of paternally transmitted genetic damage. Sperm FISH for the mouse has been used to detect chromosomally abnormal mouse sperm, while the PAINT/DAPI analysis of mouse zygotes has been used to evaluate the types of chromosomal defects that can be paternally transmitted to the embryo and their effects on embryonic development.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 2001},
month = {Thu Mar 01 00:00:00 EST 2001}
}

Conference:
Other availability
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