Mechanisms and consequences of paternally transmitted chromosomal abnormalities

Marchetti, F; Wyrobek, A J

doi:10.1002/bdrc.20040

Mechanisms and consequences of paternally transmitted chromosomal abnormalities

Journal Article · Tue Apr 05 00:00:00 EDT 2005 · Birth Defects Research Part C: Embryo Today

DOI:https://doi.org/10.1002/bdrc.20040· OSTI ID:875371

Marchetti, F; Wyrobek, A J

Paternally transmitted chromosomal damage has been associated with pregnancy loss, developmental and morphological defects, infant mortality, infertility, and genetic diseases in the offspring including cancer. There is epidemiological evidence linking paternal exposure to occupational or environmental agents with an increased risk of abnormal reproductive outcomes. There is also a large body of literature on germ cell mutagenesis in rodents showing that treatment of male germ cells with mutagens has dramatic consequences on reproduction producing effects such as those observed in human epidemiological studies. However, we know very little about the etiology, transmission and early embryonic consequences of paternally-derived chromosomal abnormalities. The available evidence suggests that: (1) there are distinct patterns of germ cell-stage differences in the sensitivity of induction of transmissible genetic damage with male postmeiotic cells being the most sensitive; (2) cytogenetic abnormalities at first metaphase after fertilization are critical intermediates between paternal exposure and abnormal reproductive outcomes; and, (3) there are maternally susceptibility factors that may have profound effects on the amount of sperm DNA damage that is converted into chromosomal aberrations in the zygote and directly affect the risk for abnormal reproductive outcomes.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

OSTI ID:: 875371

Report Number(s):: UCRL-JRNL-211336

Journal Information:: Birth Defects Research Part C: Embryo Today, Journal Name: Birth Defects Research Part C: Embryo Today Journal Issue: 2 Vol. 75

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
CHROMOSOMAL ABERRATIONS
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ETIOLOGY
FERTILIZATION
GENETICS
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INDUCTION
MALES
MITOSIS
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Mechanisms and consequences of paternally transmitted chromosomal abnormalities

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