pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy

Wang, Jiefei; Zhong, Yong; Wang, Xiao; Yang, Weitao; Bai, Feng; Zhang, Bingbo; Alarid, Leanne; Bian, Kaifu; Fan, Hongyou

doi:10.1021/acs.nanolett.7b03310

pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy

Journal Article · Wed Oct 11 00:00:00 EDT 2017 · Nano Letters

DOI:https://doi.org/10.1021/acs.nanolett.7b03310· OSTI ID:1469629

Wang, Jiefei ^[1]; Zhong, Yong ^[1]; Wang, Xiao ^[1]; Yang, Weitao ^[2]; Bai, Feng ^[3]; ^[2]; Alarid, Leanne ^[4]; Bian, Kaifu ^[4]; ^[5]

Henan Univ., Kaifeng (China). Key Lab. for Special Functional Materials of the Ministry of Education
Tongji Univ. School of Medicine, Shanghai (China). Inst. of Photomedicine. Shanghai Skin Disease Hospital. The Inst. for Biomedical Engineering & Nano Science
Henan Univ., Kaifeng (China). Key Lab. for Special Functional Materials of the Ministry of Education. Collaborative Innovation Center of Nano Functional Materials and Applications
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Univ. of New Mexico, Albuquerque, NM (United States). Dept. of Chemical and Biological Engineering; Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Structurally controlled nanoparticles, such as core–shell nanocomposite particles by combining two or more compositions, possess enhanced or new functionalities that benefited from the synergistic coupling of the two components. In this paper, we report new nanocomposite particles with self-assembled porphyrin arrays as the core surrounded by amorphous silica as the shell. The synthesis of such nanocomposite nanoparticles was conducted through a combined surfactant micelle confined self-assembly and silicate sol–gel process using optically active porphyrin as a functional building block. Depending on kinetic conditions, these particles exhibit structure and function at multiple length scales and locations. At the molecular scale, the porphyrins as the building blocks provide well-defined macromolecular structures for noncovalent self-assembly and unique chemistry for high-yield generation of singlet oxygen for photodynamic therapy (PDT). On the nanoscale, controlled noncovalent interactions of the porphyrin building block result in an extensive self-assembled porphyrin network that enables efficient energy transfer and impressive fluorescence for cell labeling, evidenced by absorption and photoluminescence spectra. The thin silicate shell on the nanoparticle surface allows easy functionalization, and the resultant targeting porphyrin-silica nanocomposites can selectively destroy tumor cells upon receiving light irradiation.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Henan Univ., Kaifeng (China); Tongji Univ. School of Medicine, Shanghai (China)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22); USDOE National Nuclear Security Administration (NNSA); National Natural Science Foundation of China (NSFC); Plan For Scientific Innovation Talent of Henan Province (China); Program for Changjiang Scholars and Innovative Research Team in University (China)

Grant/Contract Number:: NA0003525

OSTI ID:: 1469629

Report Number(s):: SAND--2018-9734J; 667619

Journal Information:: Nano Letters, Journal Name: Nano Letters Journal Issue: 11 Vol. 17; ISSN 1530-6984

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Picolyl Porphyrin Nanostructures as a Functional Drug Entrant for Photodynamic Therapy in Human Breast Cancers Marydasan, Betsy; Nair, Rajshree R.; Babu, P. S. Saneesh ACS Omega, Vol. 4, Issue 7 https://doi.org/10.1021/acsomega.9b01380	journal	July 2019
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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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photosensitizer
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self-assembly
singlet oxygen

pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy

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