Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies

Zhang, Ruiping; Cheng, Kai; Antaris, Alexander L.; Ma, Xiaowei; Yang, Min; Ramakrishnan, Sindhuja; Liu, Guifeng; Lu, Alex; Dai, Hongjie; Tian, Mei; Cheng, Zhen

doi:10.1016/j.biomaterials.2016.06.063

Title: Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies

Journal Article · Sat Jul 02 00:00:00 EDT 2016 · Biomaterials

DOI:https://doi.org/10.1016/j.biomaterials.2016.06.063· OSTI ID:1463085

Zhang, Ruiping ^[1]; Cheng, Kai ^[2]; Antaris, Alexander L. ^[3]; Ma, Xiaowei ^[2]; Yang, Min ^[2]; Ramakrishnan, Sindhuja ^[2]; Liu, Guifeng ^[2]; Lu, Alex ^[2]; Dai, Hongjie ^[3]; Tian, Mei ^[4];

^[2]

Shanxi Medical Univ. (China). Dept. of Radiology of the First Hospital of Shanxi Medical Univ. and Molecular Imaging Precision Medical Collaborative Innovation Center; Stanford Univ., CA (United States). School of Medicine, Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection and Dept. of Radiology and Bio-X Program
Stanford Univ., CA (United States). School of Medicine, Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection and Dept. of Radiology and Bio-X Program
Stanford Univ., CA (United States). Dept. of Chemistry
Zhejiang Univ., Hangzhou (China). The Second Hospital of Zhejiang Univ. School of Medicine, PET Center and Dept. of Nuclear Medicine

The multimodality theranostic system, which can integrate two or more different therapeutic modalities and multimodal imaging agents into a nanoentity, shows great promising prospects for the cancer treatment. For this, we developed an efficient and novel strategy to synthesize hybrid anisotropic nanoparticles (HANs) with intrinsic multimodal theranostic capability [chemotherapy, photothermal therapy, magnetic resonance imaging (MRI), and photoacoustic imaging (PAI)]. For the first time, under the guidance of MRI and PAI, the chemotherapy and thermotherapy induced by administration of multifunctional hybrid nanoprobes were applied simultaneously to the treatment of colon cancer-bearing mice in vivo.

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Research Organization:: Stanford Univ., CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH); National Nature Science Foundation of China (NSFC); National Key Basic Research Program of China

Grant/Contract Number:: SC0008397; CCNE-TR U54 CA119367; CA151459; P50 CA114747; 81571747; 81371628; 2015CB931800; 2015081035; 2015035; 2015057; 2011CB935801

OSTI ID:: 1463085

Alternate ID(s):: OSTI ID: 1397090

Journal Information:: Biomaterials, Vol. 103, Issue C; ISSN 0142-9612

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 34 works

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