Chelator-Free and Biocompatible Melanin Nanoplatform with Facile-Loading Gadolinium and Copper-64 for Bioimaging

Hong, Su Hyun; Sun, Yao; Tang, Chu; Cheng, Kai; Zhang, Ruiping; Fan, Quli; Xu, Liying; Huang, Daijuan; Zhao, Anthony; Cheng, Zhen

doi:10.1021/acs.bioconjchem.7b00245

Title: Chelator-Free and Biocompatible Melanin Nanoplatform with Facile-Loading Gadolinium and Copper-64 for Bioimaging

Journal Article · Thu Jun 08 00:00:00 EDT 2017 · Bioconjugate Chemistry

DOI:https://doi.org/10.1021/acs.bioconjchem.7b00245· OSTI ID:1534426

Hong, Su Hyun ^[1]; Sun, Yao ^[1]; Tang, Chu ^[2]; Cheng, Kai ^[1]; Zhang, Ruiping ^[1];

^[1]; Xu, Liying ^[1]; Huang, Daijuan ^[1]; Zhao, Anthony ^[1];

^[1]

Stanford Univ., CA (United States)
Xidian Univ., Xi’an, Shaanxi (China)

Development of a chelator-free and biocompatible platform for the facile construction of gadolinium³⁺ (Gd³⁺)-loaded nanoparticle based probes for in vivo magentic resonance imaging (MRI) is still challenging. In this work, biocompatible Gd³⁺-loading melanin dots (Gd–M-dots) have been easily prepared and have exhibited good loading efficiency for Gd³⁺, high stability, and higher T₁ relaxivity compared to the commercial Gd–1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) agent. Furthermore, Gd–M-dots showed unique photoacoustic (PA) properties, and a high PA imaging signal could be observed in vivo 1 h after injection. Compared to the traditional Gd³⁺-loaded nanoparticles for single-modal MRI, Gd–M-dots can also be radiolabeled with ⁶⁴Cu²⁺ for positron emission tomography. Overall, these attractive properties of Gd–M-dots render them a promising imaging agent for various biomedical applications.

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Research Organization:: Stanford Univ., CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH); National Natural Science Foundation of China (NSFC); Shanxi Scholarship Council of China

Grant/Contract Number:: SC0008397; P50 CA114747; 81571747; 81371628; 2015057

OSTI ID:: 1534426

Journal Information:: Bioconjugate Chemistry, Vol. 28, Issue 7; ISSN 1043-1802

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 31 works

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A novel, chelator-free method for 64Cu labeling of dendrimers Xu, Xiaoping; Li, Yi; Cao, Tianye Journal of Nanoparticle Research, Vol. 20, Issue 8 https://doi.org/10.1007/s11051-018-4291-6	journal	July 2018
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Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging Zhang, Qing; Zhou, Huijun; Chen, Hao Small, Vol. 15, Issue 45 https://doi.org/10.1002/smll.201903382	journal	September 2019
Melanin/polydopamine-based nanomaterials for biomedical applications Qi, Chao; Fu, Lian-Hua; Xu, Han Science China Chemistry, Vol. 62, Issue 2 https://doi.org/10.1007/s11426-018-9392-6	journal	January 2019
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