Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Zhang, Xiao; He, Shuqing; Ding, Bingbing; Qu, Chunrong; Zhang, Qing; Chen, Hao; Sun, Yu; Fang, Hanyi; Long, Yu; Zhang, Ruiping; Lan, Xiaoli; Cheng, Zhen

doi:10.1016/j.cej.2019.123959

Title: Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Journal Article · Fri Dec 27 00:00:00 EST 2019 · Chemical Engineering Journal

DOI:https://doi.org/10.1016/j.cej.2019.123959· OSTI ID:1801816

^[1]; He, Shuqing ^[2]; Ding, Bingbing ^[3]; Qu, Chunrong ^[3]; Zhang, Qing ^[3]; Chen, Hao ^[3]; Sun, Yu ^[3]; Fang, Hanyi ^[4]; Long, Yu ^[4]; Zhang, Ruiping ^[5]; Lan, Xiaoli ^[4];

^[3]

Stanford University, CA (United States); Huazhong University of Science and Technology, Wuhan (China)
Stanford University, CA (United States); Southern University of Science and Technology, Shenzhen (China)
Stanford University, CA (United States)
Huazhong University of Science and Technology, Wuhan (China)
The Affiliated Tumor Hospital of Shanxi Medical University, Taiyuan (China)

With the attractive characteristics of low toxicity, narrow emission spectra, long fluorescence lifetime, and no photobleaching, rare-earth doped nanoparticles (RENPs) have become promising imaging nanoplatforms in the second near-infrared window (NIR-II, 1000–1700 nm). Many studies have been devoted to different surface modification strategies of RENPs to achieve good NIR-II tumor imaging property. However, the tumor imaging efficiency of these approaches remains disappointing. Herein, two methods were pursued to modify RENPs with either polyethylene glycol (PEG) or cancer-cell-membrane to generate PEGylated-RENPs and cancer-cell-membrane camouflaged RENPs (CC-RENPs), respectively. Furthermore, this study demonstrated that cancer-cell-membrane coating of RENPs greatly improved tumor imaging performance in NIR-II window than PEG coating. Besides, CC-RENPs uptakes in liver and spleen significantly decreased. Importantly, CC-RENPs was found to be capable to aid us to pursue precise resection of the tumor. In conclusion, CC-RENPs are capable of targeting tumors and show high tumor NIR-II imaging quality. They are highly promising nanomaterials for future medical applications.

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Research Organization:: Stanford Univ., CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Natural Science Foundation of China (NSFC); China Scholarship Council (CSC)

Grant/Contract Number:: SC0008397; 81630049; 81801738; 81901783; 81571747; 81371628; 201706160068

OSTI ID:: 1801816

Alternate ID(s):: OSTI ID: 1580799

Journal Information:: Chemical Engineering Journal, Vol. 385, Issue C; ISSN 1385-8947

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 74 works

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62 RADIOLOGY AND NUCLEAR MEDICINE
Engineering
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Rare-earth doped nanoparticles
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Tumor imaging
Surgery navigation

Title: Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

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