High-Throughput Characterization of Cascade type I-E CRISPR Guide Efficacy Reveals Unexpected PAM Diversity and Target Sequence Preferences
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journal
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June 2017 |
Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
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journal
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May 2013 |
Cpf1 Is A Versatile Tool for CRISPR Genome Editing Across Diverse Species of Cyanobacteria
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journal
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December 2016 |
Rapid generation of CRISPR/dCas9-regulated, orthogonally repressible hybrid T7-lac promoters for modular, tuneable control of metabolic pathway fluxes in Escherichia coli
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journal
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April 2016 |
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
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journal
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April 2016 |
CasOT: a genome-wide Cas9/gRNA off-target searching tool
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journal
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January 2014 |
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
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journal
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October 2014 |
Homology-Integrated CRISPR–Cas (HI-CRISPR) System for One-Step Multigene Disruption in Saccharomyces cerevisiae
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journal
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September 2014 |
CRISPR/Cas9-Based Efficient Genome Editing in Clostridium ljungdahlii , an Autotrophic Gas-Fermenting Bacterium
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journal
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June 2016 |
Enhanced protein and biochemical production using CRISPRi-based growth switches
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journal
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November 2016 |
Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation
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journal
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October 2016 |
Functional annotation of native enhancers with a Cas9–histone demethylase fusion
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journal
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March 2015 |
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
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journal
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February 2017 |
Efficient gene editing in Corynebacterium glutamicum using the CRISPR/Cas9 system
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journal
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November 2017 |
CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells
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journal
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August 2015 |
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
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journal
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November 2013 |
The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages
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journal
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August 2012 |
Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design
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journal
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March 2016 |
CRISPR-Cas9 for the genome engineering of cyanobacteria and succinate production
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journal
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November 2016 |
Next generation sequencing technology: Advances and applications
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journal
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October 2014 |
Harnessing heterologous and endogenous CRISPR-Cas machineries for efficient markerless genome editing in Clostridium
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journal
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May 2016 |
CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus
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journal
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March 2014 |
Cas9 gRNA engineering for genome editing, activation and repression
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journal
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September 2015 |
CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum
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journal
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May 2017 |
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance
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journal
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December 1996 |
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
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journal
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September 2013 |
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
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journal
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June 2016 |
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
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journal
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September 2014 |
High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System
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journal
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November 2014 |
CRISPR-Cas systems for editing, regulating and targeting genomes
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journal
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March 2014 |
Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system
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journal
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July 2016 |
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
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journal
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June 2013 |
Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications
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journal
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November 2015 |
Genome editing of Clostridium autoethanogenum using CRISPR/Cas9
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journal
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October 2016 |
Editing of the Bacillus subtilis Genome by the CRISPR-Cas9 System
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journal
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June 2016 |
Digital logic circuits in yeast with CRISPR-dCas9 NOR gates
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journal
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May 2017 |
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
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journal
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November 2009 |
Rationally engineered Cas9 nucleases with improved specificity
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journal
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December 2015 |
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
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journal
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January 2007 |
CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria
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journal
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July 2017 |
Gene silencing by CRISPR interference in mycobacteria
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journal
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February 2015 |
CasEMBLR: Cas9-Facilitated Multiloci Genomic Integration of in Vivo Assembled DNA Parts in Saccharomyces cerevisiae
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journal
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March 2015 |
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
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journal
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March 2011 |
CRISPR interference as a titratable, trans-acting regulatory tool for metabolic engineering in the cyanobacterium Synechococcus sp. strain PCC 7002
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journal
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November 2016 |
DNA Replication in Eukaryotic Cells
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journal
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June 2002 |
Identification of a DNA Nonhomologous End-Joining Complex in Bacteria
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journal
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September 2002 |
Genome Engineering With Zinc-Finger Nucleases
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journal
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August 2011 |
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
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journal
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October 2015 |
Where does bacterial replication start? Rules for predicting the oriC region
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journal
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July 2004 |
Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli
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journal
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September 2015 |
The Cpf1 CRISPR-Cas protein expands genome-editing tools
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journal
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November 2015 |
Type III CRISPR-Cas Immunity: Major Differences Brushed Aside
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journal
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January 2017 |
Kinetics of the CRISPR-Cas9 effector complex assembly and the role of 3′-terminal segment of guide RNA
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journal
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March 2016 |
CRMAGE: CRISPR Optimized MAGE Recombineering
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journal
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January 2016 |
Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
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journal
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March 2013 |
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
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journal
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September 2016 |
CRISPR–Cas9-based photoactivatable transcription systems to induce neuronal differentiation
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journal
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September 2017 |
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
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journal
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January 2015 |
CRISPR–Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains
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journal
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December 2015 |
CRISPR interference (CRISPRi) for gene regulation and succinate production in cyanobacterium S. elongatus PCC 7942
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journal
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November 2016 |
CRISPathBrick: Modular Combinatorial Assembly of Type II-A CRISPR Arrays for dCas9-Mediated Multiplex Transcriptional Repression in E. coli
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journal
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April 2015 |
TAL Effectors: Customizable Proteins for DNA Targeting
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journal
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September 2011 |
Coupling the CRISPR/Cas9 System with Lambda Red Recombineering Enables Simplified Chromosomal Gene Replacement in Escherichia coli
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journal
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May 2015 |
E-CRISP: fast CRISPR target site identification
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journal
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January 2014 |
A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT
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journal
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June 2015 |
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
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journal
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May 2016 |
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
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journal
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January 2014 |
Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus
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journal
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December 2007 |
Multiplex gene regulation by CRISPR-ddCpf1
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journal
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June 2017 |
Markerless chromosomal gene deletion in Clostridium beijerinckii using CRISPR/Cas9 system
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journal
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April 2015 |
CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii
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journal
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June 2016 |
RNA editing with CRISPR-Cas13
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journal
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October 2017 |
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery
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journal
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June 2017 |
One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
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journal
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March 2015 |
CRISPR–Cas9-assisted recombineering in Lactobacillus reuteri
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journal
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July 2014 |
Directing cellular information flow via CRISPR signal conductors
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journal
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September 2016 |
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
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journal
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June 2013 |
Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library
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journal
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October 2016 |
Multiple Gene Repression in Cyanobacteria Using CRISPRi
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journal
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December 2015 |
Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach
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journal
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July 2015 |
CRISPR/Cas9-coupled recombineering for metabolic engineering of Corynebacterium glutamicum
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journal
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July 2017 |
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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journal
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January 2013 |
Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9
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journal
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September 2015 |
Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition
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journal
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September 2013 |
AT-rich region and repeated sequences – the essential elements of replication origins of bacterial replicons
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journal
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March 2012 |
CRISPR technologies for bacterial systems: Current achievements and future directions
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journal
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November 2016 |
Efficient programmable gene silencing by Cascade
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journal
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November 2014 |
Targeting cellular mRNAs translation by CRISPR-Cas9
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journal
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July 2016 |
Multi‐input CRISPR / C as genetic circuits that interface host regulatory networks
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journal
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November 2014 |
Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae
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journal
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March 2015 |
Application of CRISPRi for prokaryotic metabolic engineering involving multiple genes, a case study: Controllable P(3HB-co-4HB) biosynthesis
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journal
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May 2015 |
An updated evolutionary classification of CRISPR–Cas systems
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journal
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September 2015 |
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
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journal
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February 2013 |
One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome
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journal
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December 2008 |
Flexible guide-RNA design for CRISPR applications using Protospacer Workbench
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journal
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June 2015 |
The new frontier of genome engineering with CRISPR-Cas9
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journal
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November 2014 |
Gene transcription repression in Clostridium beijerinckii using CRISPR-dCas9 : Gene Transcription in
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journal
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June 2016 |
Programmable RNA recognition and cleavage by CRISPR/Cas9
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journal
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September 2014 |
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
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journal
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July 2013 |
Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
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journal
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December 2015 |
Functional Analysis of Bacteriophage Immunity through a Type I-E CRISPR-Cas System in Vibrio cholerae and Its Application in Bacteriophage Genome Engineering
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journal
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November 2015 |
Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli
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journal
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February 2016 |
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
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journal
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July 2013 |
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
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journal
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August 2017 |
Efficient Transcriptional Gene Repression by Type V-A CRISPR-Cpf1 from Eubacterium eligens
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journal
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April 2017 |
Harnessing Type I and Type III CRISPR-Cas systems for genome editing
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journal
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October 2015 |
Engineering Synthetic Gene Circuits in Living Cells with CRISPR Technology
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journal
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July 2016 |
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria
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journal
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June 2016 |
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
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journal
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May 2014 |
Programming cells by multiplex genome engineering and accelerated evolution
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journal
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July 2009 |
Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
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journal
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May 2014 |
Rational modular design of metabolic network for efficient production of plant polyphenol pinosylvin
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journal
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May 2017 |
Genetic circuit design automation
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journal
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March 2016 |
CRISPR-Cas9 Based Engineering of Actinomycetal Genomes
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journal
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April 2015 |
CRISPR interference-guided balancing of a biosynthetic mevalonate pathway increases terpenoid production
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journal
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November 2016 |
Genome sequence of the human malaria parasite Plasmodium falciparum
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journal
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October 2002 |
tCRISPRi: tunable and reversible, one-step control of gene expression
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journal
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December 2016 |
Diversity, classification and evolution of CRISPR-Cas systems
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journal
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June 2017 |
Multiple nucleic acid cleavage modes in divergent type III CRISPR systems
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journal
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January 2016 |
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
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journal
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October 2014 |
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
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journal
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February 2017 |
Enhancing the RNA engineering toolkit
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journal
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November 2017 |
The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation
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journal
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June 2010 |
CRISPR interference-guided multiplex repression of endogenous competing pathway genes for redirecting metabolic flux in Escherichia coli
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journal
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November 2017 |
Requirements for Pseudomonas aeruginosa Type I-F CRISPR-Cas Adaptation Determined Using a Biofilm Enrichment Assay
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journal
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August 2016 |
Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9
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journal
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March 2017 |
Development and Applications of CRISPR-Cas9 for Genome Engineering
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journal
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June 2014 |
Targeted DNA degradation using a CRISPR device stably carried in the host genome
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journal
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May 2015 |
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
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journal
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June 2015 |
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
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journal
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January 2016 |
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
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journal
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September 2013 |
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
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journal
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January 2014 |
A novel process for obtaining pinosylvin using combinatorial bioengineering in Escherichia coli
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journal
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April 2016 |
Occurrence and Diversity of CRISPR-Cas Systems in the Genus Bifidobacterium
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journal
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July 2015 |
CRISPR interference (CRISPRi) for sequence-specific control of gene expression
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journal
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October 2013 |
Systematic testing of enzyme perturbation sensitivities via graded dCas9 modulation in Saccharomyces cerevisiae
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journal
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March 2017 |
Current and future prospects for CRISPR-based tools in bacteria: CRISPR-Based Tools in Bacteria
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journal
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October 2015 |
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
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journal
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September 2017 |
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
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journal
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October 2015 |
Advances in Industrial Biotechnology Using CRISPR-Cas Systems
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journal
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February 2018 |
Bacterial DNA repair by non-homologous end joining
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journal
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November 2007 |
Tunable and Multifunctional Eukaryotic Transcription Factors Based on CRISPR/Cas
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journal
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June 2013 |
Combinatorial metabolic engineering using an orthogonal tri-functional CRISPR system
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journal
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November 2017 |
Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System
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journal
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January 2015 |
Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system
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journal
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February 2016 |
CRISPR kinetics
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journal
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July 2017 |
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
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journal
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January 2017 |
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
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journal
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April 2015 |
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
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journal
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February 2015 |
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
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journal
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March 2015 |
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
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journal
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June 2012 |
Construction of a Quadruple Auxotrophic Mutant of an Industrial Polyploid Saccharomyces cerevisiae Strain by Using RNA-Guided Cas9 Nuclease
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journal
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October 2014 |
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
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journal
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December 2008 |
CRISPR-mediated control of the bacterial initiation of replication
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journal
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April 2016 |
Beyond Native Cas9: Manipulating Genomic Information and Function
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journal
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October 2017 |
A generic strategy for CRISPR-Cas9-mediated gene tagging
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journal
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December 2015 |
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
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journal
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August 2015 |
Engineered Cpf1 variants with altered PAM specificities
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journal
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June 2017 |
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity
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journal
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February 2017 |
RNAi mechanisms and applications
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journal
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April 2008 |
The crystal structure of Cpf1 in complex with CRISPR RNA
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journal
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April 2016 |
Genome editing with engineered zinc finger nucleases
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journal
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September 2010 |
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
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journal
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April 2016 |
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
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journal
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April 2016 |
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
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journal
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April 2016 |
Development of a CRISPR/Cas9 genome editing toolbox for Corynebacterium glutamicum
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journal
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November 2017 |
CrEdit: CRISPR mediated multi-loci gene integration in Saccharomyces cerevisiae
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journal
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July 2015 |
Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
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journal
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February 2016 |
Metabolic engineering of cyanobacteria for photosynthetic 3-hydroxypropionic acid production from CO2 using Synechococcus elongatus PCC 7942
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journal
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September 2015 |
Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity
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journal
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May 2015 |
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
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journal
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February 2018 |
Multigene disruption in undomesticated Bacillus subtilis ATCC 6051a using the CRISPR/Cas9 system
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journal
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June 2016 |
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
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journal
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January 2016 |
CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973
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journal
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June 2016 |
Characterization and Exploitation of CRISPR Loci in Bifidobacterium longum
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journal
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September 2017 |
Multiplex Genome Engineering Using CRISPR/Cas Systems
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journal
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January 2013 |
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
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journal
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August 2013 |
In vivo genome editing using Staphylococcus aureus Cas9
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journal
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April 2015 |
Highly efficient Cas9-mediated transcriptional programming
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journal
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March 2015 |
RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus
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journal
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November 2014 |
Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements
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journal
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November 2015 |
A robust gene-stacking method utilizing yeast assembly for plant synthetic biology
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journal
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October 2016 |
Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system
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journal
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August 2015 |
Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus
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journal
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November 2014 |
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
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journal
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October 2017 |
A CRISPR–Cpf1 system for efficient genome editing and transcriptional repression in plants
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journal
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February 2017 |
Development of a CRISPR-Cas9 Tool Kit for Comprehensive Engineering of Bacillus subtilis
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journal
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June 2016 |
CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3
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journal
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June 2012 |
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
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journal
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December 2013 |
Rapid and marker-free refactoring of xylose-fermenting yeast strains with Cas9/CRISPR: Rapid and Marker-Free Cas9/CRISPR Refactoring
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journal
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June 2015 |
Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase
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journal
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April 2015 |
Characterizing a thermostable Cas9 for bacterial genome editing and silencing
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journal
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November 2017 |