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Title: Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Abstract

The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

Inventors:
; ; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1436688
Patent Number(s):
9,949,927
Application Number:
14/490,336
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
DOE Contract Number:
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 18
Country of Publication:
United States
Language:
English

Citation Formats

Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. United States: N. p., 2018. Web.
Xu, Ting, Dong, He, Shu, Jessica, & Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. United States.
Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Tue . "Bis-polymer lipid-peptide conjugates and nanoparticles thereof". United States. doi:. https://www.osti.gov/servlets/purl/1436688.
@article{osti_1436688,
title = {Bis-polymer lipid-peptide conjugates and nanoparticles thereof},
author = {Xu, Ting and Dong, He and Shu, Jessica and Dube, Nikhil},
abstractNote = {The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 24 00:00:00 EDT 2018},
month = {Tue Apr 24 00:00:00 EDT 2018}
}

Patent:

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