Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Xu, Ting; Dong, He; Shu, Jessica; Dube, Nikhil

Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Patent · Tue Oct 20 04:00:00 EDT 2020

OSTI ID:1771519

Xu, Ting; Dong, He; Shu, Jessica; Dube, Nikhil

The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 10,806,702

Application Number:: 15/961,111

OSTI ID:: 1771519

Country of Publication:: United States

Language:: English

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