A Numerical Model of Exchange Chromatography Through 3D Lattice Structures

Salloum, Maher; Robinson, David B.

doi:10.1002/aic.16108

A Numerical Model of Exchange Chromatography Through 3D Lattice Structures

Journal Article · Tue Jan 30 00:00:00 EST 2018 · AIChE Journal

DOI:https://doi.org/10.1002/aic.16108· OSTI ID:1421768

^[1]; Robinson, David B. ^[1]

Sandia National Lab. (SNL-CA), Livermore, CA (United States)

Rapid progress in the development of additive manufacturing technologies is opening new opportunities to fabricate structures that control mass transport in three dimensions across a broad range of length scales. We describe a structure that can be fabricated by newly available commercial 3D printers. It contains an array of regular three-dimensional flow paths that are in intimate contact with a solid phase, and thoroughly shuffle material among the paths. We implement a chemically reacting flow model to study its behavior as an exchange chromatography column, and compare it to an array of one-dimensional flow paths that resemble more traditional honeycomb monoliths. A reaction front moves through the columns and then elutes. Here, the front is sharper at all flow rates for the structure with three-dimensional flow paths, and this structure is more robust to channel width defects than the one-dimensional array.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000; NA0003525

OSTI ID:: 1421768

Alternate ID(s):: OSTI ID: 1422267

Report Number(s):: SAND--2018-1363J; 660572

Journal Information:: AIChE Journal, Journal Name: AIChE Journal Journal Issue: 5 Vol. 64; ISSN 0001-1541

Publisher:: American Institute of Chemical EngineersCopyright Statement

Country of Publication:: United States

Language:: English

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