Thirdhand Smoke: New Evidence, Challenges, and Future Directions

Jacob, Peyton; Benowitz, Neal L.; Destaillats, Hugo; Gundel, Lara; Hang, Bo; Martins-Green, Manuela; Matt, Georg E.; Quintana, Penelope J.  E.; Samet, Jonathan M.; Schick, Suzaynn F.; Talbot, Prue; Aquilina, Noel J.; Hovell, Melbourne F.; Mao, Jian-Hua; Whitehead, Todd P.

doi:10.1021/acs.chemrestox.6b00343

Thirdhand Smoke: New Evidence, Challenges, and Future Directions

Journal Article · Wed Nov 30 00:00:00 EST 2016 · Chemical Research in Toxicology

DOI:https://doi.org/10.1021/acs.chemrestox.6b00343· OSTI ID:1417595

^[1]; Benowitz, Neal L. ^[2]; Destaillats, Hugo ^[3]; Gundel, Lara ^[3]; Hang, Bo ^[4]; Martins-Green, Manuela ^[5]; Matt, Georg E. ^[6]; Quintana, Penelope J. E. ^[7]; Samet, Jonathan M. ^[8]; Schick, Suzaynn F. ^[9]; Talbot, Prue ^[5]; Aquilina, Noel J. ^[10]; Hovell, Melbourne F. ^[7]; Mao, Jian-Hua ^[4]; Whitehead, Todd P. ^[11]

Univ. of California, San Francisco, CA (United States). Division of Clinical Pharmacology and Experimental Therapeutics. Dept. of Psychiatry. Dept. of Medicine
Univ. of California, San Francisco, CA (United States). Division of Clinical Pharmacology and Experimental Therapeutics. Medical Service. Dept. of Medicine. Dept. of Bioengineering and Therapeutic Sciences. Center for Tobacco Control Research and Education
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Indoor Environment Group
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems & Engineering
Univ. of California, Riverside, CA (United States). Dept. of Cell Biology and Neuroscience
San Diego State Univ., CA (United States). Dept. of Psychology
San Diego State Univ., CA (United States). Graduate School of Public Health
Univ. of Southern California, Los Angeles, CA (United States). Dept. of Preventive Medicine. The Keck School of Medicine
Univ. of California, San Francisco, CA (United States). Division of Occupational and Environmental Medicine. School of Medicine
Univ. of Malta, Msida (Malta). Dept. of Geosciences
Univ. of California, Berkeley, CA (United States). The Center for Integrative Research on Childhood Leukemia and the Environment. School of Public Health

Thirdhand smoke (THS) is the contamination that persists after secondhand tobacco smoke has been emitted into air. It refers to the tobacco-related gases and particles that become embedded in materials, such as the carpet, walls, furniture, blankets, and toys. THS is not strictly smoke, but chemicals that adhere to surfaces from which they can be released back into the air, undergo chemical transformations and/or accumulate. Currently, the hazards of THS are not as well documented as the hazards of secondhand smoke (SHS). In this paper, we describe the distribution and chemical changes that occur as SHS is transformed into THS, studies of environmental contamination by THS, human exposure studies, toxicology studies using animal models and in vitro systems, possible approaches for avoiding exposure, remediation of THS contamination, and priorities for further research.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: California Tobacco-Related Disease Research Program (TRDRP) (United States); Dept. of Housing and Urban Development (HUD) (United States); National Inst. of Health (NIH) (United States); National Inst. on Drug Abuse (NIDA) (United States); USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1417595

Journal Information:: Chemical Research in Toxicology, Journal Name: Chemical Research in Toxicology Journal Issue: 1 Vol. 30; ISSN 0893-228X

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (115)

In vitro assessment of reproductive toxicity of tobacco smoke and its constituents Talbot, Prudence Birth Defects Research Part C: Embryo Today: Reviews, Vol. 84, Issue 1 https://doi.org/10.1002/bdrc.20120	journal	January 2008
Volatile Secondary Metabolites of Micromeria dalmaticaBenth. (Lamiaceae): Biosynthetical and Chemotaxonomical Aspects Radulović, Niko S.; Blagojević, Polina D. Chemistry & Biodiversity, Vol. 9, Issue 7 https://doi.org/10.1002/cbdv.201100429	journal	July 2012
Lung carcinogenesis by tobacco smoke Hecht, Stephen S. International Journal of Cancer, Vol. 131, Issue 12 https://doi.org/10.1002/ijc.27816	journal	October 2012
Therapies for bleomycin induced lung fibrosis through regulation of TGF-β1 induced collagen gene expression Cutroneo, Kenneth R.; White, Sheryl L.; Phan, Sem H. Journal of Cellular Physiology, Vol. 211, Issue 3 https://doi.org/10.1002/jcp.20972	journal	January 2007
The Contribution of Lead-Contaminated House Dust and Residential Soil to Children's Blood Lead Levels Lanphear, Bruce P.; Matte, Thomas D.; Rogers, John Environmental Research, Vol. 79, Issue 1 https://doi.org/10.1006/enrs.1998.3859	journal	October 1998
Krebserzeugendes Benzpyren, gewonnen aus Tabakteer Roffo, A. H. Zeitschrift für Krebsforschung, Vol. 49, Issue 5 https://doi.org/10.1007/BF01620960	journal	September 1939
Tabakmißbrauch und Lungencarcinom Müller, Franz Hermann Zeitschrift für Krebsforschung, Vol. 49, Issue 1 https://doi.org/10.1007/BF01633114	journal	January 1940
The Challenges of Limiting Exposure to THS in Vulnerable Populations Samet, Jonathan M.; Chanson, Dayana; Wipfli, Heather Current Environmental Health Reports, Vol. 2, Issue 3 https://doi.org/10.1007/s40572-015-0060-1	journal	July 2015
Collection and analysis of Nicotine as a marker for environmental tobacco smoke Hammond, S. Katharine; Leaderer, Brian P.; Roche, Anne C. Atmospheric Environment (1967), Vol. 21, Issue 2 https://doi.org/10.1016/0004-6981(87)90027-8	journal	January 1987
Unusual distribution of monomethylalkanes in Botryococcus braunii–rich samples: origin and significance Audino, Michiele; Grice, Kliti; Alexander, Robert Geochimica et Cosmochimica Acta, Vol. 65, Issue 12 https://doi.org/10.1016/S0016-7037(01)00568-3	journal	June 2001
Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys Giovino, Gary A.; Mirza, Sara A.; Samet, Jonathan M. The Lancet, Vol. 380, Issue 9842 https://doi.org/10.1016/S0140-6736(12)61085-X	journal	August 2012
Pyridines in cigarette smoke inhibit hamster oviductal functioning in picomolar doses Riveles, K. Reproductive Toxicology, Vol. 17, Issue 2 https://doi.org/10.1016/S0890-6238(02)00150-8	journal	April 2003
Pediatrician Interventions and Thirdhand Smoke Beliefs of Parents Drehmer, Jeremy E.; Ossip, Deborah J.; Rigotti, Nancy A. American Journal of Preventive Medicine, Vol. 43, Issue 5 https://doi.org/10.1016/j.amepre.2012.07.020	journal	November 2012
Gas-phase organics in environmental tobacco smoke: 2. Exposure-relevant emission factors and indirect exposures from habitual smoking Singer, Brett C.; Hodgson, Alfred T.; Nazaroff, William W. Atmospheric Environment, Vol. 37, Issue 39-40 https://doi.org/10.1016/j.atmosenv.2003.07.015	journal	December 2003
Sorption of organic gases in a furnished room Singer, Brett C.; Revzan, Kenneth L.; Hotchi, Toshifumi Atmospheric Environment, Vol. 38, Issue 16 https://doi.org/10.1016/j.atmosenv.2004.02.003	journal	May 2004
Secondary organic aerosol formation from ozone-initiated reactions with nicotine and secondhand tobacco smoke Sleiman, Mohamad; Destaillats, Hugo; Smith, Jared D. Atmospheric Environment, Vol. 44, Issue 34 https://doi.org/10.1016/j.atmosenv.2010.07.023	journal	November 2010
Light-induced nitrous acid (HONO) production from NO2 heterogeneous reactions on household chemicals Gómez Alvarez, Elena; Sörgel, Matthias; Gligorovski, Sasho Atmospheric Environment, Vol. 95 https://doi.org/10.1016/j.atmosenv.2014.06.034	journal	October 2014
Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations Chen, Hsiuchen; Vermulst, Marc; Wang, Yun E. Cell, Vol. 141, Issue 2 https://doi.org/10.1016/j.cell.2010.02.026	journal	April 2010
Rapid and sensitive gas chromatography–ion-trap tandem mass spectrometry method for the determination of tobacco-specific N-nitrosamines in secondhand smoke Sleiman, Mohamad; Maddalena, Randy L.; Gundel, Lara A. Journal of Chromatography A, Vol. 1216, Issue 45 https://doi.org/10.1016/j.chroma.2009.09.020	journal	November 2009
Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers Ramírez, Noelia; Özel, Mustafa Z.; Lewis, Alastair C. Environment International, Vol. 71 https://doi.org/10.1016/j.envint.2014.06.012	journal	October 2014
Airborne psychotropic substances in eight Italian big cities: Burdens and behaviours Cecinato, Angelo; Balducci, Catia; Romagnoli, Paola Environmental Pollution, Vol. 171 https://doi.org/10.1016/j.envpol.2012.07.033	journal	December 2012
Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community Huen, Karen; Bradman, Asa; Harley, Kim Environmental Research, Vol. 117 https://doi.org/10.1016/j.envres.2012.05.005	journal	August 2012
Determination of the nicotine metabolites cotinine and trans-3′-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography–tandem mass spectrometry: Biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity Jacob III, Peyton; Yu, Lisa; Duan, Minjiang Journal of Chromatography B, Vol. 879, Issue 3-4 https://doi.org/10.1016/j.jchromb.2010.12.012	journal	February 2011
Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1 Yuan, Hongwei; Shyy, John Y. -J.; Martins-Green, Manuela Journal of Hepatology, Vol. 51, Issue 3 https://doi.org/10.1016/j.jhep.2009.03.026	journal	September 2009
The rise of mitochondria in medicine Picard, Martin; Wallace, Douglas C.; Burelle, Yan Mitochondrion, Vol. 30 https://doi.org/10.1016/j.mito.2016.07.003	journal	September 2016
Bleomycin lung toxicity: who are the patients with increased risk? Azambuja, E.; Fleck, J. F.; Batista, R. G. Pulmonary Pharmacology & Therapeutics, Vol. 18, Issue 5 https://doi.org/10.1016/j.pupt.2005.01.007	journal	October 2005
Solid-phase supported profluorescent nitroxide probe for the determination of aerosol-borne reactive oxygen species Sleiman, Mohamad; Destaillats, Hugo; Gundel, Lara A. Talanta, Vol. 116 https://doi.org/10.1016/j.talanta.2013.08.024	journal	November 2013
Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments Bahl, Vasundhra; Shim, Hyung Jun; Jacob, Peyton Toxicology in Vitro, Vol. 32 https://doi.org/10.1016/j.tiv.2015.12.007	journal	April 2016
Subpicogram per Milliliter Determination of the Tobacco-Specific Carcinogen Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Human Urine Using Liquid Chromatography−Tandem Mass Spectrometry Jacob, Peyton; Havel, Christopher; Lee, Do-Hoon Analytical Chemistry, Vol. 80, Issue 21 https://doi.org/10.1021/ac8009005	journal	October 2008
Tobacco Alkaloids and Tobacco-Specific Nitrosamines in Dust from Homes of Smokeless Tobacco Users, Active Smokers, and Nontobacco Users Whitehead, Todd P.; Havel, Christopher; Metayer, Catherine Chemical Research in Toxicology, Vol. 28, Issue 5 https://doi.org/10.1021/acs.chemrestox.5b00040	journal	April 2015
Estimated Exposure Risks from Carcinogenic Nitrosamines in Urban Airborne Particulate Matter Farren, Naomi J.; Ramírez, Noelia; Lee, James D. Environmental Science & Technology, Vol. 49, Issue 16 https://doi.org/10.1021/acs.est.5b01620	journal	August 2015
Phase Distribution of Nicotine in Real Environments As Determined by Two Sampling Methods Loefroth, Goeran. Environmental Science & Technology, Vol. 29, Issue 4 https://doi.org/10.1021/es00004a017	journal	April 1995
Sources of Fine Organic Aerosol. 6. Cigaret Smoke in the Urban Atmosphere Rogge, Wolfgang F.; Hildemann, Lynn M.; Mazurek, Monica A. Environmental Science & Technology, Vol. 28, Issue 7 https://doi.org/10.1021/es00056a030	journal	July 1994
Solanesol: a tracer for environmental tobacco smoke particles Tang, Hongmao; Richards, Galen; Benner, Cynthia L. Environmental Science & Technology, Vol. 24, Issue 6 https://doi.org/10.1021/es00076a009	journal	June 1990
Dynamic Behavior of Semivolatile Organic Compounds in Indoor Air. 2. Nicotine and Phenanthrene with Carpet and Wallboard Van Loy, Michael D.; Riley, William J.; Daisey, Joan M. Environmental Science & Technology, Vol. 35, Issue 3 https://doi.org/10.1021/es001372a	journal	February 2001
Is House Dust the Missing Exposure Pathway for PBDEs? An Analysis of the Urban Fate and Human Exposure to PBDEs Jones-Otazo, Heather A.; Clarke, John P.; Diamond, Miriam L. Environmental Science & Technology, Vol. 39, Issue 14 https://doi.org/10.1021/es048267b	journal	July 2005
Effect of Ozone on Nicotine Desorption from Model Surfaces: Evidence for Heterogeneous Chemistry Destaillats, Hugo; Singer, Brett C.; Lee, Sharon K. Environmental Science & Technology, Vol. 40, Issue 6 https://doi.org/10.1021/es050914r	journal	March 2006
Thirdhand Smoke: Heterogeneous Oxidation of Nicotine and Secondary Aerosol Formation in the Indoor Environment Petrick, Lauren M.; Svidovsky, Alona; Dubowski, Yael Environmental Science & Technology, Vol. 45, Issue 1 https://doi.org/10.1021/es102060v	journal	January 2011
Environmental Tobacco Smoke as a Source of Polycyclic Aromatic Hydrocarbons in Settled Household Dust Hoh, Eunha; Hunt, Richard N.; Quintana, Penelope J. E. Environmental Science & Technology, Vol. 46, Issue 7 https://doi.org/10.1021/es300267g	journal	March 2012
Inhalable Constituents of Thirdhand Tobacco Smoke: Chemical Characterization and Health Impact Considerations Sleiman, Mohamad; Logue, Jennifer M.; Luo, Wentai Environmental Science & Technology, Vol. 48, Issue 22 https://doi.org/10.1021/es5036333	journal	October 2014
Photooxidation of aliphatic amines under simulated atmospheric conditions: formation of nitrosamines, nitramines, amides, and photochemical oxidant Pitts, James N.; Grosjean, Daniel; Van Cauwenberghe, Karel Environmental Science & Technology, Vol. 12, Issue 8 https://doi.org/10.1021/es60144a009	journal	August 1978
Conversion of Nicotine in Tobacco Smoke to Its Volatile and Available Free-Base Form through the Action of Gaseous Ammonia Pankow, James F.; Mader, Brian T.; Isabelle, Lorne M. Environmental Science & Technology, Vol. 31, Issue 8 https://doi.org/10.1021/es970402f	journal	August 1997
Measurements of the Hydroxyl Radical in a Manipulated but Realistic Indoor Environment Weschler, Charles J.; Shields, Helen C. Environmental Science & Technology, Vol. 31, Issue 12 https://doi.org/10.1021/es970669e	journal	December 1997
Chemical studies on tobacco smoke. 52. Reaction of nicotine and sodium nitrite: formation of nitrosamines and fragmentation of the pyrrolidine ring Hecht, Stephen S.; Chen, Chi-Hong B.; Ornaf, Raphael M. The Journal of Organic Chemistry, Vol. 43, Issue 1 https://doi.org/10.1021/jo00395a017	journal	January 1978
Nicotelline: A Proposed Biomarker and Environmental Tracer for Particulate Matter Derived from Tobacco Smoke Jacob, Peyton; Goniewicz, Maciej L.; Havel, Christopher M. Chemical Research in Toxicology, Vol. 26, Issue 11 https://doi.org/10.1021/tx400094y	journal	October 2013
Progress and Challenges in Selected Areas of Tobacco Carcinogenesis Hecht, Stephen S. Chemical Research in Toxicology, Vol. 21, Issue 1 https://doi.org/10.1021/tx7002068	journal	January 2008
Ozone in Indoor Environments: Concentration and Chemistry Weschler, Charles J. Indoor Air, Vol. 10, Issue 4 https://doi.org/10.1034/j.1600-0668.2000.010004269.x	journal	December 2000
Fussy mitochondria fuse in response to stress van der Bliek, Alexander M. The EMBO Journal, Vol. 28, Issue 11 https://doi.org/10.1038/emboj.2009.130	journal	June 2009
Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments Morgan, Marsha K.; Sheldon, Linda S.; Croghan, Carry W. Journal of Exposure Science & Environmental Epidemiology, Vol. 15, Issue 4 https://doi.org/10.1038/sj.jea.7500406	journal	September 2004
Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke Xu, Bo; Chen, Minjian; Yao, Mengmeng Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep15512	journal	October 2015
Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice Hang, Bo; Snijders, Antoine M.; Huang, Yurong Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/srep41915	journal	February 2017
Variations in the estimation of the contribution of environmental tobacco smoke (ETS) to respirable (≤5 µm) indoor air particulates obtained by the use of different analytical methods Douce, David S.; Clench, Malcolm R.; Frost, Barrie Journal of Environmental Monitoring, Vol. 3, Issue 3 https://doi.org/10.1039/b008212k	journal	January 2001
Identification of oxidation products of solanesol produced during air sampling for tobacco smoke by electrospray mass spectrometry and HPLC Tucker, Samuel P.; Pretty, Jack R. The Analyst, Vol. 130, Issue 10 https://doi.org/10.1039/b505328e	journal	January 2005
Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing Dhall, Sandeep; Alamat, Raquelle; Castro, Anthony Clinical Science, Vol. 130, Issue 14 https://doi.org/10.1042/CS20160236	journal	June 2016
Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards Sleiman, M.; Gundel, L. A.; Pankow, J. F. Proceedings of the National Academy of Sciences, Vol. 107, Issue 15 https://doi.org/10.1073/pnas.0912820107	journal	February 2010
Unexpectedly high indoor hydroxyl radical concentrations associated with nitrous acid Gomez Alvarez, E.; Amedro, D.; Afif, C. Proceedings of the National Academy of Sciences, Vol. 110, Issue 33 https://doi.org/10.1073/pnas.1308310110	journal	July 2013
Indoor Dust Exposure: An Unnoticed Aspect of Involuntary Smoking Hein, Hans Ole; Suadicani, Poul; Skov, Peder Archives of Environmental Health: An International Journal, Vol. 46, Issue 2 https://doi.org/10.1080/00039896.1991.9937435	journal	April 1991
Nicotine as a Marker for Environmental Tobacco Smoke: Implications of Sorption on Indoor Surface Materials Van Loy, Michael D.; Nazaroff, William W.; Daisey, Joan M. Journal of the Air & Waste Management Association, Vol. 48, Issue 10 https://doi.org/10.1080/10473289.1998.10463742	journal	October 1998
Residual tobacco smoke pollution in used cars for sale: Air, dust, and surfaces Matt, Georg; Quintana, Penelope; Hovell, Melbourne Nicotine & Tobacco Research, Vol. 10, Issue 9 https://doi.org/10.1080/14622200802279898	journal	September 2008
Thirdhand tobacco smoke: procedures to evaluate cytotoxicity in cell cultures Figueiró, Luciana Rizzieri; Dantas, Denise Conceição Mesquita; Linden, Rafael Toxicology Mechanisms and Methods, Vol. 26, Issue 5 https://doi.org/10.1080/15376516.2016.1188190	journal	June 2016
Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm Raupach, Tobias; Schäfer, Katrin; Konstantinides, Stavros European Heart Journal, Vol. 27, Issue 4 https://doi.org/10.1093/eurheartj/ehi601	journal	October 2005
Tobacco Smoke Carcinogens and Lung Cancer Hecht, S. S. JNCI Journal of the National Cancer Institute, Vol. 91, Issue 14 https://doi.org/10.1093/jnci/91.14.1194	journal	July 1999
Thirdhand smoke causes DNA damage in human cells Hang, B.; Sarker, A. H.; Havel, C. Mutagenesis, Vol. 28, Issue 4 https://doi.org/10.1093/mutage/get013	journal	March 2013
Counseling to reduce children's secondhand smoke exposure and help parents quit smoking: A controlled trial Hovell, M. F.; Zakarian, J. M.; Matt, G. E. Nicotine & Tobacco Research, Vol. 11, Issue 12 https://doi.org/10.1093/ntr/ntp148	journal	October 2009
Interlaboratory comparability of serum cotinine measurements at smoker and nonsmoker concentration levels: A round-robin study Bernert, John T.; Jacob, Peyton; Holiday, David B. Nicotine & Tobacco Research, Vol. 11, Issue 12 https://doi.org/10.1093/ntr/ntp161	journal	November 2009
Residual Tobacco Smoke in Used Cars: Futile Efforts and Persistent Pollutants Fortmann, A. L.; Romero, R. A.; Sklar, M. Nicotine & Tobacco Research, Vol. 12, Issue 10 https://doi.org/10.1093/ntr/ntq144	journal	August 2010
Wipe Sampling for Nicotine as a Marker of Thirdhand Tobacco Smoke Contamination on Surfaces in Homes, Cars, and Hotels Quintana, P. J. E.; Matt, G. E.; Chatfield, D. Nicotine & Tobacco Research, Vol. 15, Issue 9 https://doi.org/10.1093/ntr/ntt014	journal	March 2013
Thirdhand Tobacco Smoke: A Tobacco-Specific Lung Carcinogen on Surfaces in Smokers' Homes Thomas, J. L.; Hecht, S. S.; Luo, X. Nicotine & Tobacco Research, Vol. 16, Issue 1 https://doi.org/10.1093/ntr/ntt110	journal	July 2013
Children’s Exposure to Secondhand and Thirdhand Smoke Carcinogens and Toxicants in Homes of Hookah Smokers Kassem, Nada O. F.; Daffa, Reem M.; Liles, Sandy Nicotine & Tobacco Research, Vol. 16, Issue 7 https://doi.org/10.1093/ntr/ntu016	journal	March 2014
Cotinine as a Biomarker of Environmental Tobacco Smoke Exposure Benowitz, N. L. Epidemiologic Reviews, Vol. 18, Issue 2 https://doi.org/10.1093/oxfordjournals.epirev.a017925	journal	January 1996
Phenols, Quinolines, Indoles, Benzene, and 2-Cyclopenten-1-ones are Oviductal Toxicants in Cigarette Smoke Riveles, Karen; Roza, R.; Talbot, P. Toxicological Sciences, Vol. 86, Issue 1 https://doi.org/10.1093/toxsci/kfi112	journal	February 2005
Cigarette Smoke Toxicants Alter Growth and Survival of Cultured Mammalian Cells Yu, Richard; Wu, M.; Lin, S. Toxicological Sciences, Vol. 93, Issue 1 https://doi.org/10.1093/toxsci/kfl047	journal	June 2006
Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation Bahl, Vasundhra; Weng, Nikki J. -H.; Schick, Suzaynn F. Toxicological Sciences, Vol. 150, Issue 1 https://doi.org/10.1093/toxsci/kfv327	journal	December 2015
From the Cover: Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells Bahl, Vasundhra; Johnson, Kimberly; Phandthong, Rattapol Toxicological Sciences, Vol. 153, Issue 1 https://doi.org/10.1093/toxsci/kfw102	journal	June 2016
Correlating Atmospheric and Biological Markers in Studies of Secondhand Tobacco Smoke Exposure and Dose in Children and Adults Repace, James; Al-Delaimy, Wael K.; Bernert, John T. Journal of Occupational and Environmental Medicine, Vol. 48, Issue 2 https://doi.org/10.1097/01.jom.0000184883.72902.d4	journal	January 2006
Third-hand Smoke: Impact on Hemostasis and Thrombogenesis Karim, Zubair A.; Alshbool, Fatima Z.; Vemana, Hari Priya Journal of Cardiovascular Pharmacology, Vol. 66, Issue 2 https://doi.org/10.1097/FJC.0000000000000260	journal	January 2015
Residential Air Exchange Rates in the United States: Empirical and Estimated Parametric Distributions by Season and Climatic Region Murray, Donald M.; Burmaster, David E. Risk Analysis, Vol. 15, Issue 4 https://doi.org/10.1111/j.1539-6924.1995.tb00338.x	journal	August 1995
Residential air exchange rates in three major US metropolitan areas: results from the Relationship Among Indoor, Outdoor, and Personal Air Study 1999â€“2001 Yamamoto, N.; Shendell, D. G.; Winer, A. M. Indoor Air, Vol. 20, Issue 1 https://doi.org/10.1111/j.1600-0668.2009.00622.x	journal	February 2010
Ventilation rates and health: multidisciplinary review of the scientific literature: Ventilation rates and health Sundell, J.; Levin, H.; Nazaroff, W. W. Indoor Air, Vol. 21, Issue 3 https://doi.org/10.1111/j.1600-0668.2010.00703.x	journal	February 2011
The Faroes Statement: Human Health Effects of Developmental Exposure to Chemicals in Our Environment Grandjean, Philippe; Bellinger, David; Bergman, Åke Basic & Clinical Pharmacology & Toxicology, Vol. 0, Issue 0 https://doi.org/10.1111/j.1742-7843.2007.00114.x	journal	July 2007
Households contaminated by environmental tobacco smoke: sources of infant exposures Matt, G. E. Tobacco Control, Vol. 13, Issue 1 https://doi.org/10.1136/tc.2003.003889	journal	March 2004
When smokers move out and non-smokers move in: residential thirdhand smoke pollution and exposure Matt, G. E.; Quintana, P. J. E.; Zakarian, J. M. Tobacco Control, Vol. 20, Issue 1 https://doi.org/10.1136/tc.2010.037382	journal	October 2010
Secondhand smoke levels in public building main entrances: outdoor and indoor PM _2.5 assessment Sureda, Xisca; Martínez-Sánchez, Jose M.; López, María José Tobacco Control, Vol. 21, Issue 6 https://doi.org/10.1136/tobaccocontrol-2011-050040	journal	September 2011
Towards smoke-free rental cars: an evaluation of voluntary smoking restrictions in California Matt, Georg E.; Fortmann, Addie L.; Quintana, Penelope J. E. Tobacco Control, Vol. 22, Issue 3 https://doi.org/10.1136/tobaccocontrol-2011-050231	journal	February 2012
Environmental monitoring of secondhand smoke exposure Apelberg, Benjamin J.; Hepp, Lisa M.; Avila-Tang, Erika Tobacco Control, Vol. 22, Issue 3 https://doi.org/10.1136/tobaccocontrol-2011-050301	journal	September 2012
Associations between self-reported in-home smoking behaviours and surface nicotine concentrations in multiunit subsidised housing Hood, Nancy E.; Ferketich, Amy K.; Klein, Elizabeth G. Tobacco Control, Vol. 23, Issue 1 https://doi.org/10.1136/tobaccocontrol-2012-050666	journal	October 2012
Thirdhand smoke and exposure in California hotels: non-smoking rooms fail to protect non-smoking hotel guests from tobacco smoke exposure Matt, Georg E.; Quintana, Penelope J. E.; Fortmann, Addie L. Tobacco Control, Vol. 23, Issue 3 https://doi.org/10.1136/tobaccocontrol-2012-050824	journal	May 2013
Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK Schick, Suzaynn F.; Farraro, Kathryn F.; Perrino, Charles Tobacco Control, Vol. 23, Issue 2 https://doi.org/10.1136/tobaccocontrol-2012-050915	journal	May 2013
Thirdhand smoke contamination in hospital settings: assessing exposure risk for vulnerable paediatric patients: Table 1 Northrup, Thomas F.; Khan, Amir M.; Jacob, Peyton Tobacco Control, Vol. 25, Issue 6 https://doi.org/10.1136/tobaccocontrol-2015-052506	journal	December 2015
When smokers quit: exposure to nicotine and carcinogens persists from thirdhand smoke pollution Matt, Georg E.; Quintana, Penelope J. E.; Zakarian, Joy M. Tobacco Control, Vol. 26, Issue 5 https://doi.org/10.1136/tobaccocontrol-2016-053119	journal	September 2016
Successful Smoking Cessation in COPD: Association with Comorbidities and Mortality Kupiainen, H.; Kinnula, V. L.; Lindqvist, A. Pulmonary Medicine, Vol. 2012 https://doi.org/10.1155/2012/725024	journal	January 2012
Concentrations of the Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Sidestream Cigarette Smoke Increase after Release into Indoor Air: Results from Unpublished Tobacco Industry Research Schick, S. F.; Glantz, S. Cancer Epidemiology Biomarkers & Prevention, Vol. 16, Issue 8 https://doi.org/10.1158/1055-9965.EPI-07-0210	journal	August 2007
Urine Cotinine Underestimates Exposure to the Tobacco-Derived Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Passive Compared with Active Smokers Benowitz, Neal; Goniewicz, Maciej Lukasz; Eisner, Mark D. Cancer Epidemiology Biomarkers & Prevention, Vol. 19, Issue 11 https://doi.org/10.1158/1055-9965.EPI-10-0497	journal	August 2010
Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking Barnoya, Joaquin; Glantz, Stanton A. Circulation, Vol. 111, Issue 20 https://doi.org/10.1161/CIRCULATIONAHA.104.492215	journal	May 2005
Exposure to Secondhand Smoke and Biomarkers of Cardiovascular Disease Risk in Never-Smoking Adults Venn, Andrea; Britton, John Circulation, Vol. 115, Issue 8 https://doi.org/10.1161/CIRCULATIONAHA.106.648469	journal	February 2007
Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning Riveles, Karen; Roza, Ryan; Arey, Janet Reproductive Biology and Endocrinology, Vol. 2, Issue 1, p. 23 https://doi.org/10.1186/1477-7827-2-23	journal	January 2004
Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air Boström, Carl-Elis; Gerde, Per; Hanberg, Annika Environmental Health Perspectives, Vol. 110, Issue s3 https://doi.org/10.1289/ehp.02110s3451	journal	February 2002
Thirdhand Tobacco Smoke: Emerging Evidence and Arguments for a Multidisciplinary Research Agenda Matt, Georg E.; Quintana, Penelope J. E.; Destaillats, Hugo Environmental Health Perspectives, Vol. 119, Issue 9 https://doi.org/10.1289/ehp.1103500	journal	September 2011
Exposure to Secondhand Smoke Outside of a Bar and a Restaurant and Tobacco Exposure Biomarkers in Nonsmokers St. Helen, Gideon; Bernert, J. Thomas; Hall, Daniel B. Environmental Health Perspectives, Vol. 120, Issue 7 https://doi.org/10.1289/ehp.1104413	journal	July 2012
Agricultural and residential pesticides in wipe samples from farmworker family residences in North Carolina and Virginia. Quandt, Sara A.; Arcury, Thomas A.; Rao, Pamela Environmental Health Perspectives, Vol. 112, Issue 3 https://doi.org/10.1289/ehp.6554	journal	March 2004
In vitro approaches for determining mechanisms of toxicity and carcinogenicity by asbestos in the gastrointestinal and respiratory tracts. Mossman, B. T. Environmental Health Perspectives, Vol. 53 https://doi.org/10.1289/ehp.8353155	journal	November 1983
Ozone’s Impact on Public Health: Contributions from Indoor Exposures to Ozone and Products of Ozone-Initiated Chemistry Weschler, Charles J. Environmental Health Perspectives, Vol. 114, Issue 10 https://doi.org/10.1289/ehp.9256	journal	October 2006
Exposure to Secondhand Smoke in Terraces and Other Outdoor Areas of Hospitality Venues in Eight European Countries López, Maria J.; Fernández, Esteve; Gorini, Giuseppe PLoS ONE, Vol. 7, Issue 8 https://doi.org/10.1371/journal.pone.0042130	journal	August 2012
Cigarette Smoke Toxins Deposited on Surfaces: Implications for Human Health Martins-Green, Manuela; Adhami, Neema; Frankos, Michael PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0086391	journal	January 2014
Thirdhand Cigarette Smoke: Factors Affecting Exposure and Remediation Bahl, Vasundhra; Jacob, Peyton; Havel, Christopher PLoS ONE, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pone.0108258	journal	October 2014
Evaluating Cell Processes, Quality, and Biomarkers in Pluripotent Stem Cells Using Video Bioinformatics Zahedi, Atena; On, Vincent; Lin, Sabrina C. PLOS ONE, Vol. 11, Issue 2 https://doi.org/10.1371/journal.pone.0148642	journal	February 2016
A Health Threat to Bystanders Living in the Homes of Smokers: How Smoke Toxins Deposited on Surfaces Can Cause Insulin Resistance Adhami, Neema; Starck, Shelley R.; Flores, Cristina PLOS ONE, Vol. 11, Issue 3 https://doi.org/10.1371/journal.pone.0149510	journal	March 2016
Reactive Changes in Smokers and Arterial Disease and COPD Anthony, Honor M. Reviews on Environmental Health, Vol. 8, Issue 1-4 https://doi.org/10.1515/reveh-1989-1-405	journal	January 1989
Beliefs About the Health Effects of "Thirdhand" Smoke and Home Smoking Bans Winickoff, J. P.; Friebely, J.; Tanski, S. E. PEDIATRICS, Vol. 123, Issue 1 https://doi.org/10.1542/peds.2008-2184	journal	January 2009
Determination of Volatile Organic Compounds for a Systematic Evaluation of Third-Hand Smoking Ueta, Ikuo; Saito, Yoshihiro; Teraoka, Kenta Analytical Sciences, Vol. 26, Issue 5 https://doi.org/10.2116/analsci.26.569	journal	January 2010
Triglyceride Level Affecting Shared Susceptibility Genes in Metabolic Syndrome and Coronary Artery Disease Kisfali, P.; Polgar, N.; Safrany, E. Current Medicinal Chemistry, Vol. 17, Issue 30 https://doi.org/10.2174/092986710792927822	journal	October 2010
Mouse and Human Embryonic Stem Cells: Can They Improve Human Health by Preventing Disease? Lin, Sabrina; Talbot, Prue Current Topics in Medicinal Chemistry, Vol. 11, Issue 13 https://doi.org/10.2174/156802611796117621	journal	July 2011
Tracers for Assessing Exposure to Environmental Tobacco Smoke: What Are They Tracing? Daisey, Joan M. Environmental Health Perspectives, Vol. 107 https://doi.org/10.2307/3434424	journal	May 1999
Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts Hang, Bo Journal of Nucleic Acids, Vol. 2010 https://doi.org/10.4061/2010/709521	journal	January 2010
The effect of cigarette smoke on fertilization and pre-implantation development: assessment using animal models, clinical data, and stem cells Talbot, Prue; Lin, Sabrina Biological Research, Vol. 44, Issue 2 https://doi.org/10.4067/S0716-97602011000200011	journal	January 2011

Cited By (15)

Exposure to secondhand smoke in vehicles among Canadian adolescents: Years after the adoption of smoke-free car laws Azagba, Sunday; Latham, Keely; Shan, Lingpeng Addictive Behaviors Reports, Vol. 10 https://doi.org/10.1016/j.abrep.2019.100215	journal	December 2019
Levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in raw wastewater as an innovative perspective for investigating population-wide exposure to third-hand smoke Lai, Foon Yin; Lympousi, Katerina; Been, Frederic Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-31324-6	journal	September 2018
Pre-pregnancy maternal fasting plasma glucose levels in relation to time to pregnancy among the couples attempting first pregnancy Zhao, Jun; Hong, Xiang; Zhang, Hongguang Human Reproduction, Vol. 34, Issue 7 https://doi.org/10.1093/humrep/dez069	journal	June 2019
Home Health and Community Care Workers’ Occupational Exposure to Secondhand Smoke: A Rapid Literature Review Angus, Kathryn; Semple, Sean Nicotine & Tobacco Research, Vol. 21, Issue 12 https://doi.org/10.1093/ntr/nty226	journal	October 2018
Human transport of thirdhand tobacco smoke: A prominent source of hazardous air pollutants into indoor nonsmoking environments Sheu, Roger; Stönner, Christof; Ditto, Jenna C. Science Advances, Vol. 6, Issue 10 https://doi.org/10.1126/sciadv.aay4109	journal	March 2020
Nicotine on Children’s Hands: Limited Protection of Smoking Bans and Initial Clinical Findings Mahabee-Gittens, E. Melinda; Merianos, Ashley L.; Hoh, Eunha Tobacco Use Insights, Vol. 12 https://doi.org/10.1177/1179173x18823493	journal	January 2019
Fine particles in homes of predominantly low-income families with children and smokers: Key physical and behavioral determinants to inform indoor-air-quality interventions Klepeis, Neil E.; Bellettiere, John; Hughes, Suzanne C. PLOS ONE, Vol. 12, Issue 5 https://doi.org/10.1371/journal.pone.0177718	journal	May 2017
Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives Torres, Sònia; Merino, Carla; Paton, Beatrix International Journal of Environmental Research and Public Health, Vol. 15, Issue 12 https://doi.org/10.3390/ijerph15122693	journal	November 2018
Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models Hang, Bo; Wang, Pin; Zhao, Yue International Journal of Molecular Sciences, Vol. 18, Issue 5 https://doi.org/10.3390/ijms18050932	journal	April 2017
Inner-City Asthma in Children Poowuttikul, Pavadee; Saini, Shweta; Seth, Divya Clinical Reviews in Allergy & Immunology, Vol. 56, Issue 2 https://doi.org/10.1007/s12016-019-08728-x	journal	January 2019
The atmospheric chemistry of indoor environments Abbatt, Jonathan P. D.; Wang, Chen Environmental Science: Processes & Impacts, Vol. 22, Issue 1 https://doi.org/10.1039/c9em00386j	journal	January 2020
Thirdhand Smoke at Philip Morris Whitlatch, Adam; Schick, Suzaynn Nicotine & Tobacco Research, Vol. 21, Issue 12 https://doi.org/10.1093/ntr/nty153	journal	July 2018
Parents' Self-efficacy for Tobacco Exposure Protection and Smoking Abstinence Mediate Treatment Effects on Child Cotinine at 12-Month Follow-up: Mediation Results from the Kids Safe and Smokefree Trial Collins, Bradley N.; Lepore, Stephen J.; Winickoff, Jonathan P. Nicotine & Tobacco Research, Vol. 22, Issue 11 https://doi.org/10.1093/ntr/ntz175	journal	September 2019
Contribution of thirdhand smoke to overall tobacco smoke exposure in pediatric patients: study protocol Mahabee-Gittens, E. Melinda; Matt, Georg E.; Hoh, Eunha BMC Public Health, Vol. 19, Issue 1 https://doi.org/10.1186/s12889-019-6829-7	journal	May 2019
Public Facility Utility and Third-Hand Smoking Exposure without First and Second-Hand Smoking According to Urinary Cotinine Level Moon, Si; Kim, Tae; Kim, Yoon-Ji International Journal of Environmental Research and Public Health, Vol. 16, Issue 5 https://doi.org/10.3390/ijerph16050855	journal	March 2019

Similar Records

Thirdhand smoke: Genotoxicity and carcinogenic potential

Journal Article · Wed Sep 25 20:00:00 EDT 2019 · Chronic Diseases and Translational Medicine · OSTI ID:1637309

Update on thirdhand smoke: A comprehensive systematic review

Journal Article · Wed Nov 14 23:00:00 EST 2018 · Environmental Research · OSTI ID:23100726

Inhalation of Trace Metals in Secondhand and Thirdhand Tobacco Smoke Can Result in Increased Health Risks

Journal Article · Sun Mar 31 20:00:00 EDT 2024 · Environmental Science & Technology Letters (Online) · OSTI ID:2472919

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Thirdhand Smoke: New Evidence, Challenges, and Future Directions

Citation Formats

References (115)

Cited By (15)

Similar Records

Related Subjects