Thirdhand Smoke: New Evidence, Challenges, and Future Directions

Jacob, Peyton; Benowitz, Neal L.; Destaillats, Hugo; Gundel, Lara; Hang, Bo; Martins-Green, Manuela; Matt, Georg E.; Quintana, Penelope J.  E.; Samet, Jonathan M.; Schick, Suzaynn F.; Talbot, Prue; Aquilina, Noel J.; Hovell, Melbourne F.; Mao, Jian-Hua; Whitehead, Todd P.

doi:10.1021/acs.chemrestox.6b00343

Title: Thirdhand Smoke: New Evidence, Challenges, and Future Directions

Journal Article · Wed Nov 30 00:00:00 EST 2016 · Chemical Research in Toxicology

DOI:https://doi.org/10.1021/acs.chemrestox.6b00343· OSTI ID:1417595

^[1]; Benowitz, Neal L. ^[2]; Destaillats, Hugo ^[3]; Gundel, Lara ^[3]; Hang, Bo ^[4]; Martins-Green, Manuela ^[5]; Matt, Georg E. ^[6]; Quintana, Penelope J. E. ^[7]; Samet, Jonathan M. ^[8]; Schick, Suzaynn F. ^[9]; Talbot, Prue ^[5]; Aquilina, Noel J. ^[10]; Hovell, Melbourne F. ^[7]; Mao, Jian-Hua ^[4]; Whitehead, Todd P. ^[11]

Univ. of California, San Francisco, CA (United States). Division of Clinical Pharmacology and Experimental Therapeutics. Dept. of Psychiatry. Dept. of Medicine
Univ. of California, San Francisco, CA (United States). Division of Clinical Pharmacology and Experimental Therapeutics. Medical Service. Dept. of Medicine. Dept. of Bioengineering and Therapeutic Sciences. Center for Tobacco Control Research and Education
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Indoor Environment Group
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Systems & Engineering
Univ. of California, Riverside, CA (United States). Dept. of Cell Biology and Neuroscience
San Diego State Univ., CA (United States). Dept. of Psychology
San Diego State Univ., CA (United States). Graduate School of Public Health
Univ. of Southern California, Los Angeles, CA (United States). Dept. of Preventive Medicine. The Keck School of Medicine
Univ. of California, San Francisco, CA (United States). Division of Occupational and Environmental Medicine. School of Medicine
Univ. of Malta, Msida (Malta). Dept. of Geosciences
Univ. of California, Berkeley, CA (United States). The Center for Integrative Research on Childhood Leukemia and the Environment. School of Public Health

Thirdhand smoke (THS) is the contamination that persists after secondhand tobacco smoke has been emitted into air. It refers to the tobacco-related gases and particles that become embedded in materials, such as the carpet, walls, furniture, blankets, and toys. THS is not strictly smoke, but chemicals that adhere to surfaces from which they can be released back into the air, undergo chemical transformations and/or accumulate. Currently, the hazards of THS are not as well documented as the hazards of secondhand smoke (SHS). In this paper, we describe the distribution and chemical changes that occur as SHS is transformed into THS, studies of environmental contamination by THS, human exposure studies, toxicology studies using animal models and in vitro systems, possible approaches for avoiding exposure, remediation of THS contamination, and priorities for further research.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; California Tobacco-Related Disease Research Program (TRDRP) (United States); National Inst. on Drug Abuse (NIDA) (United States); National Inst. of Health (NIH) (United States); Dept. of Housing and Urban Development (HUD) (United States)

Grant/Contract Number:: AC02-05CH11231; 20PT-0184; 23PT-0013; 19CA-0164; 24RT-0038; 20KT-0051; 19XT-0070; 18FT-0105; 25IP-0023; 22RT-0139; 17RT-0162H; 24RT-0037H; 23DT-0103; 22DT-0002; 22RT-0141H; 19XT-0151H; 19XT-0166; 25ST-0038; 24RT-0039; P30 DA012393; S10 RR026437; CAHHU0028-15

OSTI ID:: 1417595

Journal Information:: Chemical Research in Toxicology, Vol. 30, Issue 1; ISSN 0893-228X

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 132 works

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Wipe Sampling for Nicotine as a Marker of Thirdhand Tobacco Smoke Contamination on Surfaces in Homes, Cars, and Hotels Quintana, P. J. E.; Matt, G. E.; Chatfield, D. Nicotine & Tobacco Research, Vol. 15, Issue 9 https://doi.org/10.1093/ntr/ntt014	journal	March 2013
Nicotine as a Marker for Environmental Tobacco Smoke: Implications of Sorption on Indoor Surface Materials Van Loy, Michael D.; Nazaroff, William W.; Daisey, Joan M. Journal of the Air & Waste Management Association, Vol. 48, Issue 10 https://doi.org/10.1080/10473289.1998.10463742	journal	October 1998
Thirdhand Tobacco Smoke: A Tobacco-Specific Lung Carcinogen on Surfaces in Smokers' Homes Thomas, J. L.; Hecht, S. S.; Luo, X. Nicotine & Tobacco Research, Vol. 16, Issue 1 https://doi.org/10.1093/ntr/ntt110	journal	July 2013
Environmental Tobacco Smoke as a Source of Polycyclic Aromatic Hydrocarbons in Settled Household Dust Hoh, Eunha; Hunt, Richard N.; Quintana, Penelope J. E. Environmental Science & Technology, Vol. 46, Issue 7 https://doi.org/10.1021/es300267g	journal	March 2012
Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers Ramírez, Noelia; Özel, Mustafa Z.; Lewis, Alastair C. Environment International, Vol. 71 https://doi.org/10.1016/j.envint.2014.06.012	journal	October 2014
Airborne psychotropic substances in eight Italian big cities: Burdens and behaviours Cecinato, Angelo; Balducci, Catia; Romagnoli, Paola Environmental Pollution, Vol. 171 https://doi.org/10.1016/j.envpol.2012.07.033	journal	December 2012
Exposure to Secondhand Smoke in Terraces and Other Outdoor Areas of Hospitality Venues in Eight European Countries López, Maria J.; Fernández, Esteve; Gorini, Giuseppe PLoS ONE, Vol. 7, Issue 8 https://doi.org/10.1371/journal.pone.0042130	journal	August 2012
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Associations between self-reported in-home smoking behaviours and surface nicotine concentrations in multiunit subsidised housing Hood, Nancy E.; Ferketich, Amy K.; Klein, Elizabeth G. Tobacco Control, Vol. 23, Issue 1 https://doi.org/10.1136/tobaccocontrol-2012-050666	journal	October 2012
Exposure to Secondhand Smoke Outside of a Bar and a Restaurant and Tobacco Exposure Biomarkers in Nonsmokers St. Helen, Gideon; Bernert, J. Thomas; Hall, Daniel B. Environmental Health Perspectives, Vol. 120, Issue 7 https://doi.org/10.1289/ehp.1104413	journal	July 2012
Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air Boström, Carl-Elis; Gerde, Per; Hanberg, Annika Environmental Health Perspectives, Vol. 110, Issue s3 https://doi.org/10.1289/ehp.02110s3451	journal	February 2002
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Human transport of thirdhand tobacco smoke: A prominent source of hazardous air pollutants into indoor nonsmoking environments Sheu, Roger; Stönner, Christof; Ditto, Jenna C. Science Advances, Vol. 6, Issue 10 https://doi.org/10.1126/sciadv.aay4109	journal	March 2020
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