A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Antaris, Alexander L.; Chen, Hao; Diao, Shuo; Ma, Zhuoran; Zhang, Zhe; Zhu, Shoujun; Wang, Joy; Lozano, Alexander X.; Fan, Quli; Chew, Leila; Zhu, Mark; Cheng, Kai; Hong, Xuechuan; Dai, Hongjie; Cheng, Zhen

doi:10.1038/ncomms15269

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Journal Article · Fri May 19 00:00:00 EDT 2017 · Nature Communications

DOI:https://doi.org/10.1038/ncomms15269· OSTI ID:1389584

Antaris, Alexander L. ^[1]; Chen, Hao ^[2]; Diao, Shuo ^[3]; Ma, Zhuoran ^[3]; Zhang, Zhe ^[4]; Zhu, Shoujun ^[3]; Wang, Joy ^[3]; Lozano, Alexander X. ^[3]; Fan, Quli ^[4]; ^[3]; Zhu, Mark ^[4]; Cheng, Kai ^[4]; ^[5]; Dai, Hongjie ^[3]; Cheng, Zhen ^[4]

Stanford Univ., CA (United States). Dept. of Chemistry; Stanford University
Wuhan Univ. (China). State Key Lab. of Virology, Key Lab. of Combinatorial Biosynthesis and Drug Discovery; Stanford Univ., CA (United States). Molecular Imaging Program (MIPS), Dept. of Radiology, Canary Center at Stanford for Cancer Early Detection
Stanford Univ., CA (United States). Dept. of Chemistry
Stanford Univ., CA (United States). Molecular Imaging Program (MIPS), Dept. of Radiology, Canary Center at Stanford for Cancer Early Detection
Wuhan Univ. (China). State Key Lab. of Virology, Key Lab. of Combinatorial Biosynthesis and Drug Discovery

Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with 41,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. We report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far. The bright molecular complex allowed for the fastest video-rate imaging in the second NIR window with B50-fold reduced exposure times at a fast 50 frames-per-second (FPS) capable of resolving mouse cardiac cycles. Additionally, we demonstrate that the NIR-II molecular complexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body.

View Accepted Manuscript (DOE)

Research Organization:: Stanford Univ., CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: SC0008397

OSTI ID:: 1389584

Journal Information:: Nature Communications, Journal Name: Nature Communications Vol. 8; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy Nagi, Jaspreet Singh; Skorenko, Kenneth; Bernier, William Materials, Vol. 13, Issue 1 https://doi.org/10.3390/ma13010017	journal	December 2019

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