A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Antaris, Alexander L.; Chen, Hao; Diao, Shuo; Ma, Zhuoran; Zhang, Zhe; Zhu, Shoujun; Wang, Joy; Lozano, Alexander X.; Fan, Quli; Chew, Leila; Zhu, Mark; Cheng, Kai; Hong, Xuechuan; Dai, Hongjie; Cheng, Zhen

doi:10.1038/ncomms15269

Title: A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Journal Article · Fri May 19 00:00:00 EDT 2017 · Nature Communications

DOI:https://doi.org/10.1038/ncomms15269· OSTI ID:1389584

Antaris, Alexander L. ^[1]; Chen, Hao ^[2]; Diao, Shuo ^[1]; Ma, Zhuoran ^[1]; Zhang, Zhe ^[3]; Zhu, Shoujun ^[1]; Wang, Joy ^[1]; Lozano, Alexander X. ^[1]; Fan, Quli ^[3];

^[1]; Zhu, Mark ^[3]; Cheng, Kai ^[3];

^[4]; Dai, Hongjie ^[1]; Cheng, Zhen ^[3]

Stanford Univ., CA (United States). Dept. of Chemistry
Wuhan Univ. (China). State Key Lab. of Virology, Key Lab. of Combinatorial Biosynthesis and Drug Discovery; Stanford Univ., CA (United States). Molecular Imaging Program (MIPS), Dept. of Radiology, Canary Center at Stanford for Cancer Early Detection
Stanford Univ., CA (United States). Molecular Imaging Program (MIPS), Dept. of Radiology, Canary Center at Stanford for Cancer Early Detection
Wuhan Univ. (China). State Key Lab. of Virology, Key Lab. of Combinatorial Biosynthesis and Drug Discovery

Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with 41,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. We report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far. The bright molecular complex allowed for the fastest video-rate imaging in the second NIR window with B50-fold reduced exposure times at a fast 50 frames-per-second (FPS) capable of resolving mouse cardiac cycles. Additionally, we demonstrate that the NIR-II molecular complexes are superior to clinically approved ICG for lymph node imaging deep within the mouse body.

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Research Organization:: Stanford Univ., CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0008397

OSTI ID:: 1389584

Journal Information:: Nature Communications, Vol. 8; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 381 works

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Macro- and microscopic findings of ICG fluorescence in liver tumors Shimada, Shingo; Ohtsubo, Seiji; Ogasawara, Kazuhiro World Journal of Surgical Oncology, Vol. 13, Issue 1 https://doi.org/10.1186/s12957-015-0615-5	journal	June 2015
Tm ³⁺ ‐Sensitized NIR‐II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding Zhang, Hongxin; Fan, Yong; Pei, Peng Angewandte Chemie International Edition, Vol. 58, Issue 30 https://doi.org/10.1002/anie.201903536	journal	July 2019
Beyond Phototherapy: Recent Advances in Multifunctional Fluorescent Nanoparticles for Light-Triggered Tumor Theranostics del Rosal, Blanca; Jia, Baohua; Jaque, Daniel Advanced Functional Materials, Vol. 28, Issue 44 https://doi.org/10.1002/adfm.201803733	journal	August 2018
All‐in‐One Phototheranostics: Single Laser Triggers NIR‐II Fluorescence/Photoacoustic Imaging Guided Photothermal/Photodynamic/Chemo Combination Therapy Wang, Qi; Dai, Yeneng; Xu, Jingzeng Advanced Functional Materials, Vol. 29, Issue 31 https://doi.org/10.1002/adfm.201901480	journal	April 2019
Diaminodicyanochinone – Fluoreszenzfarbstoffe mit hohem Dipolmoment und Elektronenakzeptor‐Eigenschaften Rietsch, Philipp; Witte, Felix; Sobottka, Sebastian Angewandte Chemie, Vol. 131, Issue 24 https://doi.org/10.1002/ange.201903204	journal	May 2019
Near-Infrared IIb Fluorescence Imaging of Vascular Regeneration with Dynamic Tissue Perfusion Measurement and High Spatial Resolution Ma, Zhuoran; Zhang, Mingxi; Yue, Jingying Advanced Functional Materials, Vol. 28, Issue 36 https://doi.org/10.1002/adfm.201803417	journal	July 2018
Protein-Engineered Biomaterials for Cancer Theranostics Liu, Xiaowen; Wang, Chao; Liu, Zhuang Advanced Healthcare Materials, Vol. 7, Issue 20 https://doi.org/10.1002/adhm.201800913	journal	September 2018
Programmable Chemotherapy and Immunotherapy against Breast Cancer Guided by Multiplexed Fluorescence Imaging in the Second Near-Infrared Window Hao, Xiaoxia; Li, Chunyan; Zhang, Yejun Advanced Materials, Vol. 30, Issue 51 https://doi.org/10.1002/adma.201804437	journal	October 2018
Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics Gao, Shuai; Wei, Guoguang; Zhang, Sihang Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-10056-9	journal	May 2019
First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows Hu, Zhenhua; Fang, Cheng; Li, Bo Nature Biomedical Engineering, Vol. 4, Issue 3 https://doi.org/10.1038/s41551-019-0494-0	journal	December 2019
A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery Zeng, Xiaodong; Xie, Liru; Chen, Deliang Chemical Communications, Vol. 55, Issue 95 https://doi.org/10.1039/c9cc07694h	journal	January 2019
Spinning-disc confocal microscopy in the second near-infrared window (NIR-II) Zubkovs, Vitalijs; Antonucci, Alessandra; Schuergers, Nils Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-31928-y	journal	September 2018
An IR820 Dye–Protein Complex for Second Near‐Infrared Window and Photoacoustic Imaging Du, Bulin; Qu, Chunrong; Qian, Kun Advanced Optical Materials, Vol. 8, Issue 4 https://doi.org/10.1002/adom.201901471	journal	December 2019
Precise In Vivo Inflammation Imaging Using In Situ Responsive Cross-linking of Glutathione-Modified Ultra-Small NIR-II Lanthanide Nanoparticles Zhao, Mengyao; Wang, Rui; Li, Benhao Angewandte Chemie International Edition, Vol. 58, Issue 7 https://doi.org/10.1002/anie.201812878	journal	January 2019
Specific Small‐Molecule NIR‐II Fluorescence Imaging of Osteosarcoma and Lung Metastasis Zhou, Hui; Yi, Wanrong; Li, Anguo Advanced Healthcare Materials, Vol. 9, Issue 1 https://doi.org/10.1002/adhm.201901224	journal	October 2019
Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy Nagi, Jaspreet Singh; Skorenko, Kenneth; Bernier, William Materials, Vol. 13, Issue 1 https://doi.org/10.3390/ma13010017	journal	December 2019
Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near‐Infrared Window Li, Daifeng; He, Shuqing; Wu, Yifan Advanced Science, Vol. 6, Issue 23 https://doi.org/10.1002/advs.201902042	journal	September 2019
Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy Zhang, Ruiping; Xu, Yuling; Zhang, Yi Chemical Science, Vol. 10, Issue 36 https://doi.org/10.1039/c9sc03504d	journal	January 2019
Molecular Fluorescence and Photoacoustic Imaging in the Second Near-Infrared Optical Window Using Organic Contrast Agents Jiang, Yuyan; Pu, Kanyi Advanced Biosystems, Vol. 2, Issue 5 https://doi.org/10.1002/adbi.201700262	journal	March 2018
Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery Shou, Kangquan; Tang, Yufu; Chen, Hao Chemical Science, Vol. 9, Issue 12 https://doi.org/10.1039/c8sc00206a	journal	January 2018
Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe Wang, Weizhi; Ma, Zhuoran; Zhu, Shoujun Advanced Materials, Vol. 30, Issue 22 https://doi.org/10.1002/adma.201800106	journal	April 2018
Bright AIEgen–Protein Hybrid Nanocomposite for Deep and High‐Resolution In Vivo Two‐Photon Brain Imaging Wang, Shaowei; Hu, Fang; Pan, Yutong Advanced Functional Materials, Vol. 29, Issue 29 https://doi.org/10.1002/adfm.201902717	journal	May 2019
Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy Wang, Cong; Fan, Wenpei; Zhang, Zijian Advanced Materials, Vol. 31, Issue 49 https://doi.org/10.1002/adma.201904329	journal	September 2019
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Aggregation-Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare Qi, Ji; Chen, Chao; Ding, Dan Advanced Healthcare Materials, Vol. 7, Issue 20 https://doi.org/10.1002/adhm.201800477	journal	July 2018
Enhancing Photoacoustic Intensity of Upconversion Nanoparticles by Photoswitchable Azobenzene‐Containing Polymers for Dual NIR‐II and Photoacoustic Imaging In Vivo He, Shuqing; Song, Jun; Liu, Jianfeng Advanced Optical Materials, Vol. 7, Issue 12 https://doi.org/10.1002/adom.201900045	journal	April 2019
Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission Xu, Ge; Yan, Qinglong; Lv, Xiaoguang Angewandte Chemie, Vol. 130, Issue 14 https://doi.org/10.1002/ange.201712528	journal	February 2018
“Dual Lock-and-Key”-Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near-Infrared Window Tang, Yufu; Li, Yuanyuan; Hu, Xiaoming Advanced Materials, Vol. 30, Issue 31 https://doi.org/10.1002/adma.201801140	journal	June 2018
Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging Zhang, Qing; Zhou, Huijun; Chen, Hao Small, Vol. 15, Issue 45 https://doi.org/10.1002/smll.201903382	journal	September 2019
An Activatable NIR‐II Nanoprobe for In Vivo Early Real‐Time Diagnosis of Traumatic Brain Injury Li, Chunyan; Li, Wanfei; Liu, Huanhuan Angewandte Chemie, Vol. 132, Issue 1 https://doi.org/10.1002/ange.201911803	journal	November 2019
A Novel Multimodal NIR-II Nanoprobe for the Detection of Metastatic Lymph Nodes and Targeting Chemo-Photothermal Therapy in Oral Squamous Cell Carcinoma Wang, Yufeng; Zhang, Wansu; Sun, Pengfei Theranostics, Vol. 9, Issue 2 https://doi.org/10.7150/thno.30268	journal	January 2019
Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging Zhang, Mingxi; Yue, Jingying; Cui, Ran Proceedings of the National Academy of Sciences, Vol. 115, Issue 26 https://doi.org/10.1073/pnas.1806153115	journal	June 2018
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Monitoring the Real‐Time Circulatory System‐Related Physiological and Pathological Processes In Vivo Using a Multifunctional NIR‐II Probe Li, Daifeng; Qu, Chunrong; Liu, Qiang Advanced Functional Materials, Vol. 30, Issue 6 https://doi.org/10.1002/adfm.201906343	journal	November 2019
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging Liu, Shunjie; Chen, Chao; Li, Yuanyuan Advanced Functional Materials, Vol. 30, Issue 7 https://doi.org/10.1002/adfm.201908125	journal	December 2019
Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission Xu, Ge; Yan, Qinglong; Lv, Xiaoguang Angewandte Chemie International Edition, Vol. 57, Issue 14 https://doi.org/10.1002/anie.201712528	journal	February 2018
Core–shell polymeric nanoparticles co-loaded with photosensitizer and organic dye for photodynamic therapy guided by fluorescence imaging in near and short-wave infrared spectral regions Chepurna, O. M.; Yakovliev, A.; Ziniuk, R. Journal of Nanobiotechnology, Vol. 18, Issue 1 https://doi.org/10.1186/s12951-020-0572-1	journal	January 2020
An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging Li, Benhao; Lu, Lingfei; Zhao, Mengyao Angewandte Chemie, Vol. 130, Issue 25 https://doi.org/10.1002/ange.201801226	journal	March 2018
Organic Semiconducting Agents for Deep-Tissue Molecular Imaging: Second Near-Infrared Fluorescence, Self-Luminescence, and Photoacoustics Miao, Qingqing; Pu, Kanyi Advanced Materials, Vol. 30, Issue 49 https://doi.org/10.1002/adma.201801778	journal	July 2018
Intense near-infrared-II luminescence from NaCeF ₄ :Er/Yb nanoprobes for in vitro bioassay and in vivo bioimaging Lei, Xialian; Li, Renfu; Tu, Datao Chemical Science, Vol. 9, Issue 20 https://doi.org/10.1039/c8sc00927a	journal	January 2018
An Efficient 1064 nm NIR-II Excitation Fluorescent Molecular Dye for Deep-Tissue High-Resolution Dynamic Bioimaging Li, Benhao; Lu, Lingfei; Zhao, Mengyao Angewandte Chemie International Edition, Vol. 57, Issue 25 https://doi.org/10.1002/anie.201801226	journal	March 2018
Far‐Red/Near‐Infrared Emissive (1,3‐Dimethyl)barbituric Acid‐Based AIEgens for High‐Contrast Detection of Metastatic Tumors in the Lung Gao, Heqi; Bao, Pingping; Dai, Shuxin Chemistry – An Asian Journal, Vol. 14, Issue 6 https://doi.org/10.1002/asia.201801660	journal	December 2018
Precise In Vivo Inflammation Imaging Using In Situ Responsive Cross-linking of Glutathione-Modified Ultra-Small NIR-II Lanthanide Nanoparticles Zhao, Mengyao; Wang, Rui; Li, Benhao Angewandte Chemie, Vol. 131, Issue 7 https://doi.org/10.1002/ange.201812878	journal	January 2019

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