Fabrication of co-continuous poly(ε-caprolactone)/polyglycolide blend scaffolds for tissue engineering
- German-Jordanian Univ., Amman (Jordan). Dept. of Industrial Engineering
- Iowa State Univ., Ames, IA (United States). Dept. of Industrial and Manufacturing Systems Engineering
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Science (CNMS)
The apparent inability of a single biomaterial to meet all the requirements for tissue engineering scaffolds has led to continual research in novel engineered biomaterials. One method to provide new materials and fine-tune their properties is via mixing materials. Here in this study, a biodegradable powder blend of poly(ε-caprolactone) (PCL), polyglycolide (PGA), and poly(ethylene oxide) (PEO) was prepared and three-dimensional interconnected porous PCL/PGA scaffolds were fabricated by combining cryomilling and compression molding/polymer leaching techniques. The resultant porous scaffolds exhibited co-continuous morphologies with ~50% porosity. Mean pore sizes of 24 and 56 μm were achieved by varying milling time. The scaffolds displayed high mechanical properties and water uptake, in addition to a remarkably fast degradation rate. The results demonstrate the potential of this fabrication approach to obtain PCL/PGA blend scaffolds with interconnected porosity. In general, these results provide significant insight into an approach that will lead to the development of new composites and blends in scaffold manufacturing.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- AC05-00OR22725
- OSTI ID:
- 1376314
- Journal Information:
- Journal of Applied Polymer Science, Vol. 132, Issue 35; ISSN 0021-8995
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
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