Ras gene activation in gastric adenocarcinoma of Chinese patients in Taiwan
Journal Article
·
· American Journal of Human Genetics
OSTI ID:134555
- National Cheng Kung Univ. Medical Center, Taiwan (China); and others
In order to assess the implication of mutational activation of members of the ras family of cellular proto-oncogenes in the development of gastric cancers in Chinese patients, a series of 55 cases of gastric adenocarcinoma in Taiwan was studied. Genomic deoxyribonucleic acid obtained from formalin-fixed paraffin-embedded archival tumor tissue was amplified by polymerase chain reaction and then analyzed by dot blot hybridation assay with allele-specific oligonucleotide probes to detect mutations at codons 12, 13, and 61 of c-Ki-ras, c-Ha-ras, and c-N-ras. Twelve (12.8%) of the 55 carcinomas examined harbored a point mutation. Of the 12 mutations, 8 (66.6%) were detected in Ha-ras codon 12. Our result is consistent with reports from mainland China and Korea, but different from those of Japan and the United States. This difference is probably attributable to different eating and drinking habits.
- OSTI ID:
- 134555
- Report Number(s):
- CONF-941009--
- Journal Information:
- American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: Suppl.3 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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