Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma of the oral cavity

Journal Article · Thu Sep 01 04:00:00 EDT 1994 · American Journal of Human Genetics

OSTI ID:133582

Thakker, N S; Wu, C L; Read, A P ^[1]

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1. Univ. of Manchester, (United Kingdom); and others

Loss of heterozygosity (LOH) indicative of presence of tumor suppressor genes on chromosome 3p is commonly observed in carcinomas of various tissues. We have examined LOH on chromosome 3p in 27 oral squamous cell carcinomas using 15 highly informative microsatellite polymorphisms and constructed a deletion map of chromosome 3p. Overall, LOH at one or more loci was observed in 14 tumours ({approximately}52%). A majority of these tumors ({approximately}93%) show loss in more than one area. Three distinct regions were identified. 3p13 - 3p21.1, 3p21.2 - 3p23 and 3p25. These data suggest a role for at least three tumor suppressor genes on chromosome 3p in oral squamous carcinomas. The regions of deletions overlap with those described for carcinomas of other tissues and parallel those observed in lung carcinomas. This may reflect the common etiology of the two cancers.

• OSTI ID: 133582
• Report Number(s): CONF-941009--
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: Suppl.3 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ANIMAL CELLS
BIOLOGICAL MARKERS
CARCINOMAS
CHROMOSOMAL ABERRATIONS
ETIOLOGY
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 3
ORAL CAVITY
STATISTICS