Isolation of candidate tumor suppressor genes for small cell lung cancer (SCLC) from human chromosome 3p21.3

Journal Article · Thu Sep 01 04:00:00 EDT 1994 · American Journal of Human Genetics

OSTI ID:133535

Latif, F; Zbar, B; Lerman, M ^[1]

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1. NCI-FCRDC, Frederick, MD (United States); and others

Lung cancer is the leading cause of cancer related deaths in the United States. SCLC tumors frequently display deletions on the short arm of chromosome 3 suggesting the existence of a tumor suppressor gene in this region. The region 3p21.3 is one of the common regions of deletions in lung cancer as shown by loss of heterozygosity studies and deletion mapping data and more recently by occurrence of several homozygous deletions in the same region. In our laboratory we have discovered 3 overlapping homozygous deletions in SCLC at 3p21.3. The region has been covered in YAC, p1 and cosmid contigs. Here we describe the isolation, characterization and mutational analysis of several candidate genes for SCLC in the homozygously deleted region at 3p21.3.

• OSTI ID: 133535
• Report Number(s): CONF-941009--
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: Suppl.3 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CHROMOSOMAL ABERRATIONS
CONTIGS
GENE MUTATIONS
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 3
LUNGS
NEOPLASMS
YEASTS