Plume collimation for laser ablation electrospray ionization mass spectrometry

Vertes, Akos; Stolee, Jessica A.

Title: Plume collimation for laser ablation electrospray ionization mass spectrometry

Patent · Tue Jun 07 00:00:00 EDT 2016

OSTI ID:1255956

Vertes, Akos; Stolee, Jessica A.

In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.

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Research Organization:: George Washington Univ., Washington, DC (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-01ER15129

Assignee:: The George Washington University

Patent Number(s):: 9,362,101

Application Number:: 14/477,112

OSTI ID:: 1255956

Resource Relation:: Patent File Date: 2014 Sep 04

Country of Publication:: United States

Language:: English

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Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry Vertes, Akos; Kashanchi, Fatah; Sripadi, Prabhakar https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100285446 US Patent Application 12/774533; 20100285446	patent-application	November 2010
Method and apparatus for identification of biological material van Wuijckhuijse, Arjan Laurens; Parchen, Rene https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110204220 US Patent Application 13/059947; 20110204220	patent-application	August 2011
Subcellular Analysis by Laser Ablation Electrospray Ionization Mass Spectrometry Vertes, Akos; Stolee, Jessica A.; Shrestha, Bindesh https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110215233 US Patent Application 13/045277; 20110215233	patent-application	September 2011
Three-Dimensional Molecular Imaging By Infrared Laser Ablation Electrospray Ionization Mass Spectrometry Vertes, Akos; Nemes, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110272572 US Patent Application 13/101518; 20110272572	patent-application	November 2011
Laser Ablation Electrospray Ionization (LAESI) for Atmospheric Pressure, In Vivo, and Imaging Mass Spectrometry Vertes, Akos; Nemes, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120025069 US Patent Application 13/271435; 20120025069	patent-application	February 2012
Vaporization Device and Method for Imaging Mass Spectrometry Levis, Robert J.; Brady, John J.; Judge, Elizabeth J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120149009 US Patent Application 13/390722; 20120149009	patent-application	June 2012
Three-Dimensional Molecular Imaging By Infrared Laser Ablation Electrospray Ionization Mass Spectrometry Vertes, Akos; Nemes, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120298857 US Patent Application 13/559943; 20120298857	patent-application	November 2012

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