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Plume collimation for laser ablation electrospray ionization mass spectrometry

Patent ·
OSTI ID:1255956
;
In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.
Research Organization:
The George Washington University, Washington, DC (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-01ER15129
Assignee:
The George Washington University
Patent Number(s):
9,362,101
Application Number:
14/477,112
OSTI ID:
1255956
Country of Publication:
United States
Language:
English

References (15)

Infrared laser-assisted desorption electrospray ionization mass spectrometry journal January 2008
Simultaneous Imaging of Small Metabolites and Lipids in Rat Brain Tissues at Atmospheric Pressure by Laser Ablation Electrospray Ionization Mass Spectrometry journal February 2010
Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry journal May 2006
Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV patients journal March 1999
Ambient Molecular Imaging and Depth Profiling of Live Tissue by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry journal June 2008
Free-electron-laser-based biophysical and biomedical instrumentation journal July 2003
In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry journal October 2009
Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions journal April 2005
Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization journal October 2004
Matrix-assisted laser desorption and ionization in the OH and CO absorption bands of aliphatic and aromatic matrices: dependence on laser wavelength and temporal beam profile journal December 1997
Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry journal April 2001
Three-Dimensional Imaging of Metabolites in Tissues under Ambient Conditions by Laser Ablation Electrospray Ionization Mass Spectrometry journal August 2009
Intact and top-down characterization of biomolecules and direct analysis using infrared matrix-assisted laser desorption electrospray ionization coupled to FT-ICR mass spectrometry journal April 2009
Toward Single-Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry journal March 2013
Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry journal November 2007

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