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Title: Plume collimation for laser ablation electrospray ionization mass spectrometry

Abstract

In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.

Inventors:
;
Publication Date:
Research Org.:
The George Washington University, Washington, DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1255956
Patent Number(s):
9,362,101
Application Number:
14/477,112
Assignee:
The George Washington University
DOE Contract Number:  
FG02-01ER15129
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Sep 04
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Vertes, Akos, and Stolee, Jessica A. Plume collimation for laser ablation electrospray ionization mass spectrometry. United States: N. p., 2016. Web.
Vertes, Akos, & Stolee, Jessica A. Plume collimation for laser ablation electrospray ionization mass spectrometry. United States.
Vertes, Akos, and Stolee, Jessica A. Tue . "Plume collimation for laser ablation electrospray ionization mass spectrometry". United States. https://www.osti.gov/servlets/purl/1255956.
@article{osti_1255956,
title = {Plume collimation for laser ablation electrospray ionization mass spectrometry},
author = {Vertes, Akos and Stolee, Jessica A.},
abstractNote = {In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {6}
}

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Works referenced in this record:

Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
journal, April 2001

  • Stöckle, Raoul; Setz, Patrick; Deckert, Volker
  • Analytical Chemistry, Vol. 73, Issue 7
  • DOI: 10.1021/ac001440b

Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry
journal, May 2006

  • Huang, Min-Zong; Hsu, Hsiu-Jung; Lee, Jen-Yih
  • Journal of Proteome Research, Vol. 5, Issue 5
  • DOI: 10.1021/pr050442f

Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
journal, October 2004


Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
journal, April 2005

  • Cody, Robert B.; Laramée, James A.; Durst, H. Dupont
  • Analytical Chemistry, Vol. 77, Issue 8, p. 2297-2302
  • DOI: 10.1021/ac050162j

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry
journal, November 2007

  • Nemes, Peter; Vertes, Akos
  • Analytical Chemistry, Vol. 79, Issue 21
  • DOI: 10.1021/ac071181r

In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry
journal, October 2009

  • Shrestha, Bindesh; Vertes, Akos
  • Analytical Chemistry, Vol. 81, Issue 20
  • DOI: 10.1021/ac901525g

Intact and top-down characterization of biomolecules and direct analysis using infrared matrix-assisted laser desorption electrospray ionization coupled to FT-ICR mass spectrometry
journal, April 2009

  • Sampson, Jason S.; Murray, Kermit K.; Muddiman, David C.
  • Journal of the American Society for Mass Spectrometry, Vol. 20, Issue 4, p. 667-673
  • DOI: 10.1016/j.jasms.2008.12.003

Infrared laser-assisted desorption electrospray ionization mass spectrometry
journal, January 2008

  • Rezenom, Yohannes H.; Dong, Jianan; Murray, Kermit K.
  • The Analyst, Vol. 133, Issue 2
  • DOI: 10.1039/B715146B

Free-electron-laser-based biophysical and biomedical instrumentation
journal, July 2003

  • Edwards, G. S.; Austin, R. H.; Carroll, F. E.
  • Review of Scientific Instruments, Vol. 74, Issue 7
  • DOI: 10.1063/1.1584078

Matrix-assisted laser desorption and ionization in the OH and CO absorption bands of aliphatic and aromatic matrices: dependence on laser wavelength and temporal beam profile
journal, December 1997

  • Cramer, Rainer; Haglund, Richard F.; Hillenkamp, Franz
  • International Journal of Mass Spectrometry and Ion Processes, Vol. 169-170, p. 51-67
  • DOI: 10.1016/S0168-1176(97)00223-1

Three-Dimensional Imaging of Metabolites in Tissues under Ambient Conditions by Laser Ablation Electrospray Ionization Mass Spectrometry
journal, August 2009

  • Nemes, Peter; Barton, Alexis A.; Vertes, Akos
  • Analytical Chemistry, Vol. 81, Issue 16
  • DOI: 10.1021/ac900745e

Ambient Molecular Imaging and Depth Profiling of Live Tissue by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry
journal, June 2008

  • Nemes, Peter; Barton, Alexis A.; Li, Yue
  • Analytical Chemistry, Vol. 80, Issue 12
  • DOI: 10.1021/ac8004082

Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV patients
journal, March 1999


Toward Single-Cell Analysis by Plume Collimation in Laser Ablation Electrospray Ionization Mass Spectrometry
journal, March 2013

  • Stolee, Jessica A.; Vertes, Akos
  • Analytical Chemistry, Vol. 85, Issue 7
  • DOI: 10.1021/ac303347n