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Title: Subcellular analysis by laser ablation electrospray ionization mass spectrometry

Patent ·
OSTI ID:1164685
; ;

In various embodiments, a method of laser ablation electrospray ionization mass spectrometry (LAESI-MS) may generally comprise micro-dissecting a cell comprising at least one of a cell wall and a cell membrane to expose at least one subcellular component therein, ablating the at least one subcellular component by an infrared laser pulse to form an ablation plume, intercepting the ablation plume by an electrospray plume to form ions, and detecting the ions by mass spectrometry.

Research Organization:
George Washington Univ., Washington, DC (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-01ER15129
Assignee:
George Washington University (Washington, DC)
Patent Number(s):
8,901,487
Application Number:
13/045,277
OSTI ID:
1164685
Resource Relation:
Patent File Date: 2011 Mar 10
Country of Publication:
United States
Language:
English

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