Nucleotide Sequence Studies in Microsomal Ribonucleic Acids of Normal and Rous Sarcoma Virus-Infected Tissues
A characterization of nucleotide sequence in ribonucleic acids (RNAs) in tumors would be of importance to the understanding of the structure of these molecules in neoplastic tissues. Methods for the separation of mono- and oligonucleotides liberated with ribonuclase digestion by ion exchange chromatography have been developed and applied to amino acid acceptor RNAs with promising results. This communication describes an investigation of some nucleotide sequences in microsomal RNA extracts from normal and Rous sarcoma virus-infected tissues. These are initial studies of a program designed to analyze the structure of the nuclear and cytoplasmic RNAs of normal and tumor cells.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States); Sloan-Kettering Institute for Cancer Research, Rye, NY (United States)
- Sponsoring Organization:
- US Atomic Energy Commission (AEC)
- DOE Contract Number:
- AT(30-2)-GEN-16
- OSTI ID:
- 12491294
- Report Number(s):
- BNL--6867
- Journal Information:
- Nature, Journal Name: Nature Vol. 199; ISSN 0028-0836
- Publisher:
- Macmillan, London
- Country of Publication:
- United States
- Language:
- English
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