Toxin activity assays, devices, methods and systems therefor

Koh, Chung-Yan; Schaff, Ulrich Y.; Sommer, Gregory Jon

Toxin activity assays, devices, methods and systems therefor

Patent · Tue Apr 05 04:00:00 EDT 2016

OSTI ID:1245452

Koh, Chung-Yan; Schaff, Ulrich Y.; Sommer, Gregory Jon

Embodiments of the present invention are directed toward devices, system and method for conducting toxin activity assay using sedimentation. The toxin activity assay may include generating complexes which bind to a plurality of beads in a fluid sample. The complexes may include a target toxin and a labeling agent, or may be generated due to presence of active target toxin and/or labeling agent designed to be incorporated into complexes responsive to the presence of target active toxin. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a lower density than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.

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Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Number(s):: 9,304,128

Application Number:: 14/157,278

OSTI ID:: 1245452

Country of Publication:: United States

Language:: English

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