Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy

Champion, Christophe; Quinto, Michele A.; Monti, Juan M.; Galassi, Mariel E.; Weck, Philippe F.; Fojon, Omar A.; Hanssen, Jocelyn; Rivarola, Roberto D.

doi:10.1088/0031-9155/60/20/7805

Water versus DNA: New insights into proton track-structure modeling in radiobiology and radiotherapy

Journal Article · Fri Sep 25 00:00:00 EDT 2015 · Physics in Medicine and Biology

DOI:https://doi.org/10.1088/0031-9155/60/20/7805· OSTI ID:1236225

Champion, Christophe ^[1]; Quinto, Michele A. ^[1]; Monti, Juan M. ^[2]; Galassi, Mariel E. ^[2]; Weck, Philippe F. ^[3]; Fojon, Omar A. ^[2]; Hanssen, Jocelyn ^[2]; Rivarola, Roberto D. ^[2]

Univ. de Bordeaux, CNRS/IN2P3, Gradignan (France)
CONICET and Univ. Nacional de Rosario, Rosario (Argentina)
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Water is a common surrogate of DNA for modelling the charged particle-induced ionizing processes in living tissue exposed to radiations. The present study aims at scrutinizing the validity of this approximation and then revealing new insights into proton-induced energy transfers by a comparative analysis between water and realistic biological medium. In this context, a self-consistent quantum mechanical modelling of the ionization and electron capture processes is reported within the continuum distorted wave-eikonal initial state framework for both isolated water molecules and DNA components impacted by proton beams. Their respective probability of occurrence-expressed in terms of total cross sections-as well as their energetic signature (potential and kinetic) are assessed in order to clearly emphasize the differences existing between realistic building blocks of living matter and the controverted water-medium surrogate. Thus the consequences in radiobiology and radiotherapy will be discussed in particular in view of treatment planning refinement aiming at better radiotherapy strategies.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1236225

Alternate ID(s):: OSTI ID: 22505166

Report Number(s):: SAND--2015-1838J; 579662

Journal Information:: Physics in Medicine and Biology, Journal Name: Physics in Medicine and Biology Journal Issue: 20 Vol. 60; ISSN 0031-9155

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

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