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Accurate and rapid micromixer for integrated microfluidic devices

Patent ·
OSTI ID:1221397
; ; ;
The invention may provide a microfluidic mixer having a droplet generator and a droplet mixer in selective fluid connection with the droplet generator. The droplet generator comprises first and second fluid chambers that are structured to be filled with respective first and second fluids that can each be held in isolation for a selectable period of time. The first and second fluid chambers are further structured to be reconfigured into a single combined chamber to allow the first and second fluids in the first and second fluid chambers to come into fluid contact with each other in the combined chamber for a selectable period of time prior to being brought into the droplet mixer.
Research Organization:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-06ER64249;
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
9,138,700
Application Number:
12/863,276
OSTI ID:
1221397
Country of Publication:
United States
Language:
English

References (11)

Reactions in Droplets in Microfluidic Channels journal November 2006
Rapid Mixing Using Two-Phase Hydraulic Focusing in Microchannels journal March 2005
Effects of viscosity on droplet formation and mixing in microfluidic channels journal April 2004
Micromixers—a review on passive and active mixing principles journal April 2005
High-Throughput DNA Droplet Assays Using Picoliter Reactor Volumes journal September 2007
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents journal November 2003
Micromixing of Miscible Liquids in Segmented Gas−Liquid Flow journal February 2005
A Microfabricated Rotary Pump journal January 2001
Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels journal December 2003
From The Cover: Systematic investigation of protein phase behavior with a microfluidic formulator journal September 2004
Microfluidics: Fluid physics at the nanoliter scale journal October 2005

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