Rapid microfluidic thermal cycler for nucleic acid amplification
A system for thermal cycling a material to be thermal cycled including a microfluidic heat exchanger; a porous medium in the microfluidic heat exchanger; a microfluidic thermal cycling chamber containing the material to be thermal cycled, the microfluidic thermal cycling chamber operatively connected to the microfluidic heat exchanger; a working fluid at first temperature; a first system for transmitting the working fluid at first temperature to the microfluidic heat exchanger; a working fluid at a second temperature, a second system for transmitting the working fluid at second temperature to the microfluidic heat exchanger; a pump for flowing the working fluid at the first temperature from the first system to the microfluidic heat exchanger and through the porous medium; and flowing the working fluid at the second temperature from the second system to the heat exchanger and through the porous medium.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC52-07NA27344
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Number(s):
- 9,170,060
- Application Number:
- 12/270,348
- OSTI ID:
- 1224444
- Country of Publication:
- United States
- Language:
- English
Isothermal surface production and regulation for high heat flux applications utilizing porous inserts
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journal | August 2001 |
On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets
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journal | March 2008 |
Rapid microfluidic thermal cycler for polymerase chain reaction nucleic acid amplification
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journal | May 2008 |
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