Induction of metallothionein synthesis in transplanted murine tumors by X irradiation
- Kitasato Institute Medical Center Hospital, Kitamoto Saitama (Japan)
- Jikei Univ. School of Medicine, Tokyo (Japan); and others
Although recent studies have shown that radiation can induce metallothionein (MT) synthesis in normal tissues, the induction of tumor MT synthesis by irradiation has not been reported. We examined the accumulation of MT in the Meth-A tumor (mouse fibrosarcoma cells) transplanted into mice exposed to whole-body X irradiation. In the present study, the MT content in the tumor cells was increased by X irradiation in a dose-dependent manner. The MT level induced in the tumor cells by X irradiation was elevated not only after a single exposure but also after repeated exposures. Several studies have shown that MT is one of the important cellular factors in resistance to various anti-cancer drugs and ionizing radiation. Thus our results suggest that the radiation-induced MT in the tumor cells may have to be taken into consideration when designing protocols for radio-and chemotherapy. 29 refs., 3 figs.
- OSTI ID:
- 121706
- Journal Information:
- Radiation Research, Vol. 143, Issue 1; Other Information: PBD: Jul 1995
- Country of Publication:
- United States
- Language:
- English
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