Correlation of radiobiological assays of hypoxic fraction with phosphorus-31 magnetic resonance spectroscopy across multiple tumor lines

Journal Article · Sat Jul 01 04:00:00 EDT 1995 · Radiation Research

OSTI ID:121705

Shi-Jiang, L; Guan-Yuan, J; Fish, B L ^[1]

---

1. Medical College of Wisconsin, Milwaukee, WI (United States)

Hypoxic fractions were measured in multiple tumor models and compared to {sup 31}P magnetic resonance spectroscopy (MRS) parameters. Hypoxic fractions were measured by excision assays in intramuscular and subcutaneous RIF-1 tumors, large and small SCCVII tumors, and KHT tumors. The hypoxic fractions ranged from 3% (small SCCVII) to 21% (KHT). Measurements of {sup 31}P MRS parameters (indices of tumor metabolism) were made under the same conditions used in the hypoxic fraction assays. The PCr/P{sub i} ratios in five tumor models were strongly correlated (r{sup 2}=0.98, {tau} = 1.00, P < 0.02) with their hypoxic fractions, and the NTP/P{sub i} ratio was weakly correlated (r{sup 2} = 0.67, {tau} = 0.60, P < 0.17) with hypoxic fraction. Smaller values of the PCr/P{sub i} and NTP/P{sub i} ratios were found in the tumors with larger hypoxic fractions. These experiments indicate that {sup 31}P MRS may provide a relative measurment of hypoxic fractions across different tumor lines that can be applied non-invasively to individual tumors. 42 refs., 5 figs., 4 tabs.

• OSTI ID: 121705
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 143; ISSN RAREAE; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANOXIA
BIOASSAY
COMPARATIVE EVALUATIONS
MAGNETIC RESONANCE
METABOLISM
OPTIMIZATION
PHOSPHORUS 31
RADIOASSAY
RADIOSENSITIVITY
RADIOTHERAPY
SPECTROSCOPY
TUMOR CELLS