Prediction of tumor radiosensitivity by hexafluoromisonidazole retention monitored by sup 1 H/ sup 19 F magnetic resonance spectroscopy
- Department of Radiology, Medical College of Wisconsin, Milwaukee (USA)
Hexafluoromisonidazole (CCI-103F) is a hypoxic cell label that can be measured by in vivo {sup 1}H/{sup 19}F magnetic resonance spectroscopy (MRS). The retention of CCI-103F in SCCVII tumors was found to be correlated with tumor size, with larger tumors retaining more label. Such a correlation was anticipated, as larger SCCVII tumors have larger hypoxic fractions. A significant but less strong correlation was also found between CCI-103F retention and the fraction of tumor cells surviving after 10 Gy irradiation, with tumors that retained larger amounts of CCI-103F having higher surviving fractions. These results indicated that non-invasive MRS measurement of CCI-103F retention could predict radiosensitivity in SCCVII tumors. The lack of a strong correlation between CCI-103F retention and radiosensitivity, however, indicated that hypoxic fraction was not the only factor influencing radiosensitivity in these tumors.
- OSTI ID:
- 5555630
- Journal Information:
- Cancer Communications; (United States), Journal Name: Cancer Communications; (United States) Vol. 3:5; ISSN CNCME; ISSN 0955-3541
- Country of Publication:
- United States
- Language:
- English
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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BARYONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL NEOPLASMS
FERMIONS
FLUORINE 19
FLUORINE ISOTOPES
FORECASTING
GAMMA RADIATION
HADRONS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MICE
MISONIDAZOLE
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTONS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIZERS
RESONANCE
RETENTION
RODENTS
SPECTRA
STABLE ISOTOPES
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES