The neurological effects of brevetoxin on neonatal rats
- Medical Univ. of South Carolina, Charleston, SC (United States); and others
We have investigated the neuroexcitatory and neurodegenerative effects of brevetoxin on neonatal rats. Brevetoxin, a marine-biotoxin that has been implicated in several seafood poisoning incidents, is produced by the dinoflagellate Gymnodinium brevis. Four studies were done: dose response, northern analysis, immunohistochemistry and neurodegeneration. We found that neonatal rats are much more sensitive to brevetoxin than adult rats. The effectiveness of c-fos as a biomarker is being investigated, because of the high basal expression in young animals. The neurodegeneration, although not available yet, should provide valuable information.
- Research Organization:
- Medical Univ. of South Carolina, Charleston, SC (United States)
- OSTI ID:
- 121307
- Report Number(s):
- DOE/EW/50625--T25; ON: DE95016555
- Country of Publication:
- United States
- Language:
- English
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