Antibody to prevent the effects of brevetoxin poisoning in conscious rats. Interim report
Technical Report
·
OSTI ID:7162203
The marine dinoflagellate, Ptychodiscus brevis, primarily responsible for Florida red tides, produces toxins that cause massive fish kills in the Gulf of Mexico and along the Florida coast. In humans, these toxins (brevetoxins) also cause a respiratory tract irritation from contact with seaspray and an intoxication known as neurotoxic shellfish poisoning. These toxins may be considered as potential biological warfare threat agents; therefore, finding a method of prophylaxis and therapy is imperative. The purpose of this study was to determine if an anti-brevetoxin (PbTx-2) antibody could prevent the effects seen in rats in previous brevetoxin studies, namely, reduced respiratory rates, reduced core and peripheral body temperatures, and ECG abnormalities.
- Research Organization:
- Army Medical Research Inst. of Infectious Diseases, Fort Detrick, MD (USA)
- OSTI ID:
- 7162203
- Report Number(s):
- AD-A-192646/8/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIBODIES
ANTIGENS
ANTITOXINS
BIOLOGICAL WARFARE AGENTS
BODY TEMPERATURE
CHEMICAL REACTIONS
COASTAL REGIONS
DINOFLAGELLATE
FEDERAL REGION IV
FLORIDA
INVERTEBRATES
MAMMALS
MASTIGOPHORA
MATERIALS
MEDICINE
MICROORGANISMS
NORTH AMERICA
PREVENTIVE MEDICINE
PROTOZOA
RATS
REDUCTION
RESPIRATORY SYSTEM
RODENTS
THERAPY
TOXIC MATERIALS
TOXINS
USA
VERTEBRATES
WEAPONS
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIBODIES
ANTIGENS
ANTITOXINS
BIOLOGICAL WARFARE AGENTS
BODY TEMPERATURE
CHEMICAL REACTIONS
COASTAL REGIONS
DINOFLAGELLATE
FEDERAL REGION IV
FLORIDA
INVERTEBRATES
MAMMALS
MASTIGOPHORA
MATERIALS
MEDICINE
MICROORGANISMS
NORTH AMERICA
PREVENTIVE MEDICINE
PROTOZOA
RATS
REDUCTION
RESPIRATORY SYSTEM
RODENTS
THERAPY
TOXIC MATERIALS
TOXINS
USA
VERTEBRATES
WEAPONS