Age and gender specific biokinetic model for strontium in humans

Journal Article · Sun Mar 01 04:00:00 EST 2015 · Journal of Radiological Protection: Official Journal of the Society for Radiological Protection, 35(1):87-127

DOI:https://doi.org/10.1088/0952-4746/35/1/87· OSTI ID:1183624

Shagina, N. B.; Tolstykh, E. I.; Degteva, M. O.; Anspaugh, L. R.; Napier, Bruce A.

A biokinetic model for strontium in humans is necessary for quantification of internal doses due to strontium radioisotopes. The ICRP-recommended biokinetic model for strontium has limitation for use in a population study, because it is not gender specific and does not cover all age ranges. The extensive Techa River data set on 90Sr in humans (tens of thousands of measurements) is a unique source of data on long-term strontium retention for men and women of all ages at intake. These, as well as published data, were used for evaluation of age- and gender-specific parameters for a new compartment biokinetic model for strontium (Sr-AGe model). The Sr-AGe model has similar structure as the ICRP model for the alkaline earth elements. The following parameters were mainly reevaluated: gastro-intestinal absorption and parameters related to the processes of bone formation and resorption defining calcium and strontium transfers in skeletal compartments. The Sr-AGe model satisfactorily describes available data sets on strontium retention for different kinds of intake (dietary and intravenous) at different ages (0–80 years old) and demonstrates good agreement with data sets for different ethnic groups. The Sr-AGe model can be used for dose assessment in epidemiological studies of general population exposed to ingested strontium radioisotopes.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1183624
• Report Number(s): PNNL-SA-105651; HU2006300
• Journal Information: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection, 35(1):87-127, Journal Name: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection, 35(1):87-127
• Country of Publication: United States
• Language: English

Related Subjects

Strontium
age dependence
biokinetics
gender dependence
model