A biokinetic model for systemic nickel

Melo, Dunstana; Leggett, Richard Wayne

doi:10.1097/HP.0000000000000579

Title: A biokinetic model for systemic nickel

Full Record
Other Related Research

Abstract

The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.

Authors:

Melo, Dunstana ^[1]; Leggett, Richard Wayne ^[2]

Melohill Technology LLC, Rockville, MD (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Publication Date:: 2017-01-01

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: Work for Others (WFO)

OSTI Identifier:: 1336598

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Journal Article: Accepted Manuscript

Journal Name:: Health Physics

Additional Journal Information:: Journal Volume: 112; Journal Issue: 1; Journal ID: ISSN 0017-9078

Publisher:: Health Physics Society

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; biokinetics nickel occupational exposure radionuclides

Citation Formats


                    Melo, Dunstana, and Leggett, Richard Wayne. A biokinetic model for systemic nickel.  United States: N. p., 2017. 
        Web.  doi:10.1097/HP.0000000000000579.

Copy to clipboard


                    Melo, Dunstana, & Leggett, Richard Wayne. A biokinetic model for systemic nickel.  United States.  https://doi.org/10.1097/HP.0000000000000579

Copy to clipboard


                    Melo, Dunstana, and Leggett, Richard Wayne. 2017.  
        "A biokinetic model for systemic nickel".  United States.  https://doi.org/10.1097/HP.0000000000000579.  https://www.osti.gov/servlets/purl/1336598.

Copy to clipboard


                    
@article{osti_1336598,

  title        = {A biokinetic model for systemic nickel},

  author       = {Melo, Dunstana and Leggett, Richard Wayne},

  abstractNote = {The International Commission on Radiological Protection (ICRP) is updating its suite of reference biokinetic models for internally deposited radionuclides. This paper reviews data for nickel and proposes an updated biokinetic model for systemic (absorbed) nickel in adult humans for use in radiation protection. Compared with the ICRP s current model for nickel, the proposed model is based on a larger set of observations of the behavior of nickel in human subjects and laboratory animals and provides a more realistic description of the paths of movement of nickel in the body. For the two most important radioisotopes of nickel, 59Ni and 63Ni, the proposed model yields substantially lower dose estimates per unit of activity reaching blood than the current ICRP model.},

  doi          = {10.1097/HP.0000000000000579},

  url          = {https://www.osti.gov/biblio/1336598},
  journal      = {Health Physics},

  issn         = {0017-9078},

  number       = 1,

  volume       = 112,

  place        = {United States},

  year         = {2017},

  month        = {1}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

https://doi.org/10.1097/HP.0000000000000579

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 1 work

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

A biokinetic model for systemic technetium in adult humans

Journal Article Leggett, Richard; Giussani, Augusto - Journal of Radiological Protection

The International Commission on Radiological Protection (ICRP) currently is updating its biokinetic and dosimetric models for internally deposited radionuclides. Technetium (Tc), the lightest element that exists only in radioactive form, has two important isotopes from the standpoint of potential risk to humans: the long-lived isotope⁹⁹Tm(T_1/2=2.1x10⁵ y) is present in high concentration in nuclear waste, and the short-lived isotope ^99mTc (T_1/2=6.02 h) is the most commonly used radionuclide in diagnostic nuclear medicine. This paper reviews data on the biological behavior of technetium and proposes a biokinetic model for systemic technetium in the adult human body for use in radiation protection.more »« less
Cited by 10
https://doi.org/10.1088/0952-4746/35/2/297

Full Text Available
Proposed biokinetic model for phosphorus

Journal Article Leggett, Richard - Journal of Radiological Protection

This paper reviews data related to the biokinetics of phosphorus in the human body and proposes a biokinetic model for systemic phosphorus for use in updated International Commission on Radiological Protection (ICRP) guidance on occupational intake of radionuclides. Compared with the ICRP s current occupational model for phosphorus (Publication 68, 1994) the proposed model provides a more realistic description of the paths of movement of phosphorus in the body and improved consistency with experimental, medical, and environmental data on the time-dependent distribution and retention of phosphorus following uptake to blood. For acute uptake of 32P to blood, the proposed modelmore »« less
https://doi.org/10.1088/0952-4746/34/2/417
Biokinetic models for radiocesium and its progeny

Journal Article Leggett, Richard - Journal of Radiological Protection

Over the next few years the International Commission on Radiological Protection (ICRP) will publish a series of reports containing updated biokinetic and dosimetric models and dose coefficients for occupational intake of radionuclides. The biokinetic modeling scheme continues a trend in modern ICRP reports toward physiologically realistic descriptions of the time-dependent behavior of absorbed radionuclides and ingrowing chain members. This paper proposes systemic biokinetic models for cesium isotopes and their chain members for use in these ICRP reports and examines dosimetric implications of the proposed models. Comparisons of A = tissue dose per unit input to blood based on current ICRPmore »« less
https://doi.org/10.1088/0952-4746/33/1/123
A biokinetic model for manganese for use in radiation protection

Journal Article Leggett, Richard - Science of the Total Environment, The

The ICRP is updating its recommendations regarding occupational exposure to radionuclides including the biokinetic models used to derive dose coefficients and assess bioassay data for internally deposited radionuclides. This report reviews biokinetic data for manganese and proposes a biokinetic model for systemic manganese consistent with the current database. The model provides a more detailed and biologically realistic description of the movement of absorbed manganese in the body than the model currently recommended by the International Commission on Radiological Protection (ICRP). The proposed model and current ICRP model yield broadly similar estimates of dose per unit activity of inhaled or ingestedmore »« less
https://doi.org/10.1016/j.scitotenv.2011.07.003
A biokinetic model for systemic sodium

Journal Article Samuels, Caleigh; Leggett, Richard - Journal of Radiological Protection

This paper describes an updated biokinetic model for systemic sodium (Na), developed for use in a series of reports by the International Commission on Radiological Protection (ICRP) on occupational intake of radionuclides. In contrast to the ICRP's previous model for intake of radio-sodium by workers, the updated model depicts realistic directions of movement of Na in the body including recycling of activity between blood and tissues. The updated model structure facilitates extension of the baseline transfer coefficients for adults to different age groups and to special exposure scenarios such as transfer of radio-sodium from the mother to the foetus ormore »« less
https://doi.org/10.1088/1361-6498/ac1499

Full Text Available

Similar Records