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Title: Mutant E. coli strain with increased succinic acid production

Abstract

A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which has been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria.

Inventors:
; ;
Publication Date:
Research Org.:
Univ. of Chicago, IL (United States); Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176700
Patent Number(s):
RE37393
Application Number:
09/429,693
Assignee:
The University of Chicago (Chicago, IL)
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Donnelly, Mark, Millard, Cynthia S., and Stols, Lucy. Mutant E. coli strain with increased succinic acid production. United States: N. p., 2001. Web.
Donnelly, Mark, Millard, Cynthia S., & Stols, Lucy. Mutant E. coli strain with increased succinic acid production. United States.
Donnelly, Mark, Millard, Cynthia S., and Stols, Lucy. 2001. "Mutant E. coli strain with increased succinic acid production". United States. https://www.osti.gov/servlets/purl/1176700.
@article{osti_1176700,
title = {Mutant E. coli strain with increased succinic acid production},
author = {Donnelly, Mark and Millard, Cynthia S. and Stols, Lucy},
abstractNote = {A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which has been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria.},
doi = {},
url = {https://www.osti.gov/biblio/1176700}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2001},
month = {9}
}