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Title: Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate

Abstract

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
The Board of Trustees of the University of Illinois, Urbana, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1172760
Patent Number(s):
8,980,185
Application Number:
13/818,569
Assignee:
The Board of Trustees of the University of Illinois (Urbana, IL)
DOE Contract Number:  
FG02-08ER64682
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Aug 25
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats

Reichert, David E, Kenis, Paul J. A., Wheeler, Tobias D, Desai, Amit V, Zeng, Dexing, and Onal, Birce C. Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate. United States: N. p., 2015. Web.
Reichert, David E, Kenis, Paul J. A., Wheeler, Tobias D, Desai, Amit V, Zeng, Dexing, & Onal, Birce C. Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate. United States.
Reichert, David E, Kenis, Paul J. A., Wheeler, Tobias D, Desai, Amit V, Zeng, Dexing, and Onal, Birce C. Tue . "Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate". United States. https://www.osti.gov/servlets/purl/1172760.
@article{osti_1172760,
title = {Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate},
author = {Reichert, David E and Kenis, Paul J. A. and Wheeler, Tobias D and Desai, Amit V and Zeng, Dexing and Onal, Birce C},
abstractNote = {A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {3}
}

Patent:

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