Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate

Reichert, David E; Kenis, Paul J. A.; Wheeler, Tobias D; Desai, Amit V; Zeng, Dexing; Onal, Birce C

Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate

Patent · Tue Mar 17 04:00:00 EDT 2015

OSTI ID:1172760

Reichert, David E; Kenis, Paul J. A.; Wheeler, Tobias D; Desai, Amit V; Zeng, Dexing; Onal, Birce C

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

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Research Organization:: The Board of Trustees of the University of Illinois, Urbana, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-08ER64682

Assignee:: The Board of Trustees of the University of Illinois (Urbana, IL)

Patent Number(s):: 8,980,185

Application Number:: 13/818,569

OSTI ID:: 1172760

Country of Publication:: United States

Language:: English

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