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Coaxial microreactor for particle synthesis

Patent ·
OSTI ID:1107604

A coaxial fluid flow microreactor system disposed on a microfluidic chip utilizing laminar flow for synthesizing particles from solution. Flow geometries produced by the mixing system make use of hydrodynamic focusing to confine a core flow to a small axially-symmetric, centrally positioned and spatially well-defined portion of a flow channel cross-section to provide highly uniform diffusional mixing between a reactant core and sheath flow streams. The microreactor is fabricated in such a way that a substantially planar two-dimensional arrangement of microfluidic channels will produce a three-dimensional core/sheath flow geometry. The microreactor system can comprise one or more coaxial mixing stages that can be arranged singly, in series, in parallel or nested concentrically in parallel.

Research Organization:
SNL (Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States))
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
8,563,325
Application Number:
12/893,915
OSTI ID:
1107604
Country of Publication:
United States
Language:
English

References (16)

Investigations of micrometer sample stream profiles in a three-dimensional hydrodynamic focusing device journal June 2008
Three-dimensional hydrodynamic focusing in a microfluidic Coulter counter journal April 2008
Spatially-resolved analysis of nanoparticle nucleation and growth in a microfluidic reactor journal January 2007
Micromachined pre-focused M × N flow switches for continuous multi-sample injection journal October 2001
Three-Dimensional Hydrodynamic Focusing in Polydimethylsiloxane (PDMS) Microchannels journal August 2004
“Microfluidic drifting”—implementing three-dimensional hydrodynamic focusing with a single-layer planar microfluidic device journal January 2007
Fluorescence lifetime imaging microscopy for in situ observation of the nanocrystallization of rubrene in a microfluidic set-up journal September 2007
PIV measurements in a microfluidic 3D-sheathing structure with three-dimensional flow behaviour journal October 2002
On-line analysis of CdSe nanoparticle formation in a continuous flow chip-based microreactor journal January 2004
Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels journal March 2005
Laminar-Flow Fluid Mixer for Fast Fluorescence Kinetics Studies journal November 2002
Radial Particle Displacements in Poiseuille Flow of Suspensions journal January 1961
Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter journal January 2003
Controlling fine particle formation processes using a concentric microreactor journal January 2006
Passive micromixers for applications in the microreactor and μTAS fields journal April 2005
Three-dimensional hydrodynamic focusing in two-layer polydimethylsiloxane (PDMS) microchannels journal June 2007

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