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Title: Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy

Abstract

There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.

Inventors:
; ; ; ;
Publication Date:
Research Org.:
The Curators of the University of Missouri, Columbia, MO, (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174538
Patent Number(s):
6,635,235
Application Number:
09/602,487
Assignee:
The Curators of the University of Missouri (Columbia, MO) OSTI
DOE Contract Number:
FG02-89ER60875
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Katti, Kattesh V., Prabhu, Kandikere R., Gali, Hariprasad, Pillarsetty, Nagavara Kishore, and Volkert, Wynn A. Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy. United States: N. p., 2003. Web.
Katti, Kattesh V., Prabhu, Kandikere R., Gali, Hariprasad, Pillarsetty, Nagavara Kishore, & Volkert, Wynn A. Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy. United States.
Katti, Kattesh V., Prabhu, Kandikere R., Gali, Hariprasad, Pillarsetty, Nagavara Kishore, and Volkert, Wynn A. Tue . "Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy". United States. doi:. https://www.osti.gov/servlets/purl/1174538.
@article{osti_1174538,
title = {Bifunctional chelating agent for the design and development of site specific radiopharmaceuticals and biomolecule conjugation strategy},
author = {Katti, Kattesh V. and Prabhu, Kandikere R. and Gali, Hariprasad and Pillarsetty, Nagavara Kishore and Volkert, Wynn A.},
abstractNote = {There is provided a method of labeling a biomolecule with a transition metal or radiometal in a site specific manner to produce a diagnostic or therapeutic pharmaceutical compound by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radio metal or a transition metal, and covalently linking the resulting metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. Also provided is a method of synthesizing the --PR.sub.2 containing biomolecules by synthesizing a P.sub.2 N.sub.2 -bifunctional chelating agent intermediate, complexing the intermediate with a radiometal or a transition metal, and covalently linking the resulting radio metal-complexed bifunctional chelating agent with a biomolecule in a site specific manner. There is provided a therapeutic or diagnostic agent comprising a --PR.sub.2 containing biomolecule.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 21 00:00:00 EDT 2003},
month = {Tue Oct 21 00:00:00 EDT 2003}
}

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