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Modulation of Rhamm (CD168) for selective adipose tissue development

Patent ·
OSTI ID:1130537
;
Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.
Research Organization:
LBNL (Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States))
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-05CH11231
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,715,653
Application Number:
12/515,405
OSTI ID:
1130537
Country of Publication:
United States
Language:
English

References (34)

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 -Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds journal April 2002
Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation journal July 1995
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60 APPLIED LIFE SCIENCES