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Title: Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting

Abstract

This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplasmonic ruler provides a fast and convenient platform for mapping nucleic acid-protein interactions, for nuclease activity monitoring, and for other footprinting related methods.

Inventors:
; ;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1107635
Patent Number(s):
8,569,468
Application Number:
12/440,579
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Chen, Fanqing Frank, Liu, Gang L, and Lee, Luke P. Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting. United States: N. p., 2013. Web.
Chen, Fanqing Frank, Liu, Gang L, & Lee, Luke P. Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting. United States.
Chen, Fanqing Frank, Liu, Gang L, and Lee, Luke P. Tue . "Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting". United States. https://www.osti.gov/servlets/purl/1107635.
@article{osti_1107635,
title = {Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting},
author = {Chen, Fanqing Frank and Liu, Gang L and Lee, Luke P},
abstractNote = {This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplasmonic ruler provides a fast and convenient platform for mapping nucleic acid-protein interactions, for nuclease activity monitoring, and for other footprinting related methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {10}
}

Patent:

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