Radiation Leukemogenesis at Low Dose Rates
Abstract
The major goals of this program were to study the efficacy of low dose rate radiation exposures for the induction of acute myeloid leukemia (AML) and to characterize the leukemias that are caused by radiation exposures at low dose rate. An irradiator facility was designed and constructed that allows large numbers of mice to be irradiated at low dose rates for protracted periods (up to their life span). To the best of our knowledge this facility is unique in the US and it was subsequently used to study radioprotectors being developed for radiological defense (PLoS One. 7(3), e33044, 2012) and is currently being used to study the role of genetic background in susceptibility to radiation-induced lung cancer. One result of the irradiation was expected; low dose rate exposures are ineffective in inducing AML. However, another result was completely unexpected; the irradiated mice had a very high incidence of hepatocellular carcinoma (HCC), approximately 50%. It was unexpected because acute exposures are ineffective in increasing HCC incidence above background. This is a potential important finding for setting exposure limits because it supports the concept of an 'inverse dose rate effect' for some tumor types. That is, for the development of some tumormore »
- Authors:
- Publication Date:
- Research Org.:
- Colorado State University, CO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1093865
- Report Number(s):
- DOE-CSU-63946-3
TRN: US1400018
- DOE Contract Number:
- FG02-05ER63946
- Resource Type:
- Technical Report
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 61 RADIATION PROTECTION AND DOSIMETRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; low dose rate radiation
Citation Formats
Weil, Michael, and Ullrich, Robert. Radiation Leukemogenesis at Low Dose Rates. United States: N. p., 2013.
Web. doi:10.2172/1093865.
Weil, Michael, & Ullrich, Robert. Radiation Leukemogenesis at Low Dose Rates. United States. https://doi.org/10.2172/1093865
Weil, Michael, and Ullrich, Robert. Wed .
"Radiation Leukemogenesis at Low Dose Rates". United States. https://doi.org/10.2172/1093865. https://www.osti.gov/servlets/purl/1093865.
@article{osti_1093865,
title = {Radiation Leukemogenesis at Low Dose Rates},
author = {Weil, Michael and Ullrich, Robert},
abstractNote = {The major goals of this program were to study the efficacy of low dose rate radiation exposures for the induction of acute myeloid leukemia (AML) and to characterize the leukemias that are caused by radiation exposures at low dose rate. An irradiator facility was designed and constructed that allows large numbers of mice to be irradiated at low dose rates for protracted periods (up to their life span). To the best of our knowledge this facility is unique in the US and it was subsequently used to study radioprotectors being developed for radiological defense (PLoS One. 7(3), e33044, 2012) and is currently being used to study the role of genetic background in susceptibility to radiation-induced lung cancer. One result of the irradiation was expected; low dose rate exposures are ineffective in inducing AML. However, another result was completely unexpected; the irradiated mice had a very high incidence of hepatocellular carcinoma (HCC), approximately 50%. It was unexpected because acute exposures are ineffective in increasing HCC incidence above background. This is a potential important finding for setting exposure limits because it supports the concept of an 'inverse dose rate effect' for some tumor types. That is, for the development of some tumor types low dose rate exposures carry greater risks than acute exposures.},
doi = {10.2172/1093865},
url = {https://www.osti.gov/biblio/1093865},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2013},
month = {9}
}