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Method for forming polymerized microfluidic devices

Patent ·
OSTI ID:1033939
 [1];  [2];  [3];  [4];  [2];  [1]
  1. Livermore, CA
  2. Tracy, CA
  3. Pleasanton, CA
  4. Danville, CA
+ Show Author Affiliations
Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.
Research Organization:
Sandia National Laboratories (SNL-CA)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Livermore, CA)
Patent Number(s):
8,047,829
Application Number:
12/321,881
OSTI ID:
1033939
Country of Publication:
United States
Language:
English

References (7)

Ultra rapid prototyping of microfluidic systems using liquid phase photopolymerization journal January 2002
Robust polymer microfluidic device fabrication via contact liquid photolithographic polymerization (CLiPP) journal January 2004
Bio-particle separation using microfluidic porous plug for environmental monitoring journal January 2007
Initiation and kinetics of thiol-ene photopolymerizations without photoinitiators journal January 2004
3D polymeric microfluidic device fabrication via contact liquid photolithographic polymerization (CLiPP) journal January 2006
Microfluidic tectonics: A comprehensive construction platform for microfluidic systems journal November 2000
In situ fabrication of macroporous polymer networks within microfluidic devices by living radical photopolymerization and leaching journal January 2005

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