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Title: Method for selective immobilization of macromolecules on self assembled monolayer surfaces

Abstract

Disclosed is a method for selective chemical binding and immobilization of macromolecules on solid supports in conjunction with self-assembled monolayer (SAM) surfaces. Immobilization involves selective binding of peptides and other macromolecules to SAM surfaces using reactive landing (RL) of mass-selected, gas phase ions. SAM surfaces provide a simple and convenient platform for tailoring chemical properties of a variety of substrates. The invention finds applications in biochemistry ranging from characterization of molecular recognition events at the amino acid level and identification of biologically active motifs in proteins, to development of novel biosensors and substrates for stimulated protein and cell adhesion.

Inventors:
 [1];  [2]
  1. Richland, WA
  2. Billerica, MA
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1032634
Patent Number(s):
8,067,053
Application Number:
12/151,945
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Laskin, Julia, and Wang, Peng. Method for selective immobilization of macromolecules on self assembled monolayer surfaces. United States: N. p., 2011. Web.
Laskin, Julia, & Wang, Peng. Method for selective immobilization of macromolecules on self assembled monolayer surfaces. United States.
Laskin, Julia, and Wang, Peng. Tue . "Method for selective immobilization of macromolecules on self assembled monolayer surfaces". United States. https://www.osti.gov/servlets/purl/1032634.
@article{osti_1032634,
title = {Method for selective immobilization of macromolecules on self assembled monolayer surfaces},
author = {Laskin, Julia and Wang, Peng},
abstractNote = {Disclosed is a method for selective chemical binding and immobilization of macromolecules on solid supports in conjunction with self-assembled monolayer (SAM) surfaces. Immobilization involves selective binding of peptides and other macromolecules to SAM surfaces using reactive landing (RL) of mass-selected, gas phase ions. SAM surfaces provide a simple and convenient platform for tailoring chemical properties of a variety of substrates. The invention finds applications in biochemistry ranging from characterization of molecular recognition events at the amino acid level and identification of biologically active motifs in proteins, to development of novel biosensors and substrates for stimulated protein and cell adhesion.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 29 00:00:00 EST 2011},
month = {Tue Nov 29 00:00:00 EST 2011}
}

Patent:

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